Reactome | CRFB4 [plasma membrane]

CRFB4 [plasma membrane]

Stable Identifier

R-DRE-448423

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

IL10RB, A0FJH9

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-10 signaling (Danio rerio)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)
        
        IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
    - Interleukin-20 family signaling (Danio rerio)
      - IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
      - IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
      - IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        IL10RB:TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
      - p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:p-STAT1, p-STAT3 [plasma membrane] (Danio rerio)
        
        IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RB:p-TYK2 [plasma membrane] (Danio rerio)
        
        Homologues of IL10RB [plasma membrane] (Danio rerio)
        
        CRFB4 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0FJH9

Gene Names

CRFB4

Reference Genes

BioGPS Gene:797527 CRFB4

CTD Gene:797527 CRFB4

ENSEMBL:ENSDARG00000068711

KEGG Gene (Danio rerio):797527 CRFB4

Monarch:797527 CRFB4

NCBI Gene:797527 CRFB4

Reference Transcript

RefSeq:NM_001083868.1 CRFB4

Participates

as a member of

Homologues of IL10RB [plasma membrane] (Danio rerio)

Other forms of this molecule

CRFB4 [extracellular region]

CRFB4 [plasma membrane]

phospho-CRFB4 [plasma membrane]

CRFB4 [plasma membrane]

Inferred From

IL10RB [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001077337.1

ZFIN

ZDB-GENE-070905-3