Reactome | tas1r2.2 [plasma membrane]

tas1r2.2 [plasma membrane]

Stable Identifier

R-DRE-444666

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

TAS1R1, A4PHQ8

Locations in the PathwayBrowser

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Sensory Perception (Danio rerio)

- Sensory perception of taste (Danio rerio)
  - Sensory perception of sweet, bitter, and umami (glutamate) taste (Danio rerio)
    - L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Danio rerio)
      - L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)
      - TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3:L-Glu [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3:L-Glu [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Danio rerio)
      - T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3:L-Glu [plasma membrane] (Danio rerio)
        
        TAS1R1:TAS1R3 [plasma membrane] (Danio rerio)
        
        Homologues of TAS1R1 [plasma membrane] (Danio rerio)
        
        tas1r2.2 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A4PHQ8

Gene Names

tas1r2.2

Reference Genes

BioGPS Gene:664686 tas1r2.2

CTD Gene:664686 tas1r2.2

ENSEMBL:ENSDARG00000059397

KEGG Gene (Danio rerio):664686 tas1r2.2

Monarch:664686 tas1r2.2

NCBI Gene:664686 tas1r2.2

Reference Transcript

RefSeq:NM_001083856.1 tas1r2.2

Participates

as a member of

Homologues of TAS1R1 [plasma membrane] (Danio rerio)

Inferred From

TAS1R1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001077325.1

ZFIN

ZDB-GENE-070917-2

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