Reactome | pik3cd [plasma membrane]

pik3cd [plasma membrane]

Stable Identifier

R-DRE-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

PIK3CD, F1RB17

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - RET signaling (Danio rerio)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Signaling by the B Cell Receptor (BCR) (Danio rerio)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Danio rerio)
        
        BCAP Signalosome [plasma membrane] (Danio rerio)
        
        PIK3CD:PIK3R1 [plasma membrane] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        PIK3CD:PIK3R1 [plasma membrane] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
      - Regulation of signaling by CBL (Danio rerio)
        
        CBL ubiquitinates PI3K (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K delta [cytosol] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)

Signal Transduction (Danio rerio)

- Intracellular signaling by second messengers (Danio rerio)
  - PIP3 activates AKT signaling (Danio rerio)
    - Negative regulation of the PI3K/AKT network (Danio rerio)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
        
        PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        Activator:PI3K [plasma membrane] (Danio rerio)
        
        BCAP Signalosome [plasma membrane] (Danio rerio)
        
        PIK3CD:PIK3R1 [plasma membrane] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)
    - PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
      - Activator:PI3K [plasma membrane] (Danio rerio)
        
        BCAP Signalosome [plasma membrane] (Danio rerio)
        
        PIK3CD:PIK3R1 [plasma membrane] (Danio rerio)
        
        pik3cd [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:F1RB17

Gene Names

pik3cd

Reference Genes

ENSEMBL:ENSDARG00000003250

Other Identifiers

13141219

13304150

394174

A_15_P110012

CJ012398

CJ012408

CJ012763

CJ012777

CJ013240

CJ013253

CJ013313

CJ013330

CJ013400

CJ013416

CJ014474

CJ014481

CUST_1807_PI428451958

CUST_18910_PI428451953

DRER00636

ENSDART00000006120

ENSDART00000006120_1

ENSDART00000006120_2

GO:0003674

GO:0006629

GO:0007165

GO:0008150

GO:0009058

GO:0014065

GO:0016301

GO:0035004

GO:0046854

GO:0048015

GT_Spec_NM_201199.1_54051

JP011514

JP011527

LOL01536

LOL02043

LOL04803

LOL04804

LOL04806

LOL04810

LOL05350

LOLS14091

MADDr01000132

NM_201199

XM_696049

XM_697384

Participates

as a component of

Other forms of this molecule

pik3cd [cytosol]

Inferred From

PIK3CD [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSDART00000006120, ENSDARG00000003250, ENSDARP00000017757

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