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IGF1,2 [extracellular region]
Stable Identifier
R-DRE-381451
Type
Set [DefinedSet]
Species
Danio rerio
Compartment
extracellular region
Synonyms
Insulin-like Growth Factor
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
Exocytosis of platelet alpha granule contents (Danio rerio)
Platelet alpha granule contents [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Metabolism of proteins (Danio rerio)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Danio rerio)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP3:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Formation of the IGF:IGFBP3:ALS complex (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP3:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Formation of the IGF:IGFBP5:ALS complex (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP5:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGFBP1 binds IGF forming IGF:IGFBP1 (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP1 [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP2 [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGFBP6 binds IGF forming IGF:IGFBP6 (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP6 [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP3:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP5:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP3:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF:IGFBP3:ALS [extracellular region] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1,2 binds IGF1R (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:IGF1R autophosphorylates (Danio rerio)
IGF1,2:IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Danio rerio)
IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
SHC-related events triggered by IGF1R (Danio rerio)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1R phosphorylates SHC1 (Danio rerio)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
p-3Y-SHC1 dissociates from IGF1R (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Danio rerio)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Danio rerio)
IGF1,2 [extracellular region] (Danio rerio)
Participants
members
igf1 [extracellular region] (Danio rerio)
igf2b [extracellular region] (Danio rerio)
Participant Of
hasMember
Platelet alpha granule contents [extracellular region]
output
Cathepsin G proteolyzes IGF:IGFBP3:ALS
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
PAPP-A2 proteolyzes IGF:IGFBP5:ALS
Plasmin proteolyzes IGF:IGFBP-3:ALS
Thrombin proteolyzes IGF:IGFBP3:ALS
input
Formation of the IGF:IGFBP3:ALS complex
Formation of the IGF:IGFBP5:ALS complex
IGF1,2 binds IGF1R
IGFBP1 binds IGF forming IGF:IGFBP1
IGFBP2 binds IGF forming IGF:IGFBP2
IGFBP6 binds IGF forming IGF:IGFBP6
hasComponent
IGF1,2:IGF1R [plasma membrane]
IGF1,2:p-3Y-IGF1R [plasma membrane]
IGF:IGFBP1 [extracellular region]
IGF:IGFBP2 [extracellular region]
IGF:IGFBP3:ALS [extracellular region]
IGF:IGFBP5:ALS [extracellular region]
IGF:IGFBP6 [extracellular region]
Inferred From
IGF1,2 [extracellular region] (Homo sapiens)
Insulin-like growth factors [extracellular region] (Homo sapiens)
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