Reactome | 5Hyl-COL2A1(182-1241) [extracellular region]

5Hyl-COL2A1(182-1241) [extracellular region]

Stable Identifier

R-DRE-2127364

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

F1QP85

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Axon guidance (Danio rerio)
  - NCAM signaling for neurite out-growth (Danio rerio)
    - NCAM1 interactions (Danio rerio)
      - Interaction of NCAM1 with collagens (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        NCAM-1:Collagen complex [plasma membrane] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)

Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Assembly of collagen fibrils and other multimeric structures (Danio rerio)
    - Collagen XI cross-links with collagen II (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen type XI fibril:Collagen type II fibril [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Formation of collagen fibres (Danio rerio)
      - Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type II fibre [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibre [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Formation of collagen fibrils (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Type X collagen associates with collagen type II fibrils (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen type X:type II fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)
      - Collagen type I, II fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen type I,II:XII,XIV fibrils [extracellular region] (Danio rerio)
        
        Collagen type I, II fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Removal of fibrillar collagen C-propeptides (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
- Degradation of the extracellular matrix (Danio rerio)
  - Collagen degradation (Danio rerio)
    - Collagen type II degradation by MMP1,3,8,13,PRSS2 (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Collagen type II degradation by MMP15 (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
- ECM proteoglycans (Danio rerio)
  - COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)
    - COMP interactors [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - COMP pentamer:COMP interactors [extracellular region] (Danio rerio)
      - COMP interactors [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - DCN binds collagen I, II, III, VI fibrils (Danio rerio)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - VTN binds collagens II, III and V (Danio rerio)
    - Collagen types II, III, V [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - VTN:Collagen types II,III,V [extracellular region] (Danio rerio)
      - Collagen types II, III, V [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
- FN1 binds Collagen types I-V, VII (Danio rerio)
  - Collagen types I-V, VII [extracellular region] (Danio rerio)
    - Collagen type II fibril [extracellular region] (Danio rerio)
      - Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Danio rerio)
    - Collagen types I-V, VII [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
- Integrin cell surface interactions (Danio rerio)
  - Collagen type II binds integrin alpha10beta1 (Danio rerio)
    - Collagen type II fibril [extracellular region] (Danio rerio)
      - Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - Integrin alpha10beta1:Collagen type II fibril:Mg2+ [plasma membrane] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
- Non-integrin membrane-ECM interactions (Danio rerio)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Danio rerio)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Danio rerio)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
      - Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Danio rerio)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by MET (Danio rerio)
    - MET promotes cell motility (Danio rerio)
      - MET activates PTK2 signaling (Danio rerio)
        
        PTK2 binds activated MET (Danio rerio)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Danio rerio)
        
        Collagen, laminin, fibronectin [extracellular region] (Danio rerio)
        
        Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type II fibre [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
        
        Collagen type XI fibre [extracellular region] (Danio rerio)
        
        Collagen type XI fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type XI [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - PDGF binds to extracellular matrix proteins (Danio rerio)
      - Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)
      - PDGF A and B chains:ECM complex [extracellular region] (Danio rerio)
        
        Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type II fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type II [extracellular region] (Danio rerio)
        
        Collagen alpha-1(II) chains [extracellular region] (Danio rerio)
        
        5Hyl-COL2A1(182-1241) [extracellular region] (Danio rerio)