Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pik3r3a [cytosol]
Stable Identifier
R-DRE-205223
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
PIK3R3, A0A0R4IUJ2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
RET signaling (Danio rerio)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Regulation of T cell activation by CD28 family (Danio rerio)
Co-stimulation by CD28 (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
CD28:PI3K [plasma membrane] (Danio rerio)
Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Interleukin-7 signaling (Danio rerio)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Danio rerio)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Danio rerio)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Danio rerio)
PI3K regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Danio rerio)
PI3K regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PIK3C(1) [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
CD28:PI3K [plasma membrane] (Danio rerio)
Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
CD28:PI3K [plasma membrane] (Danio rerio)
Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
G alpha (q) inhibits PI3K alpha (Danio rerio)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
PI3K binds membrane-associated estrogen receptors (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Direct recruitment of PI3K to p-KIT (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
RAC1 GTPase cycle (Danio rerio)
RAC1 binds effectors at the plasma membrane (Danio rerio)
RAC1 effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC1:GTP:RAC1 effectors [plasma membrane] (Danio rerio)
RAC1 effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC2 GTPase cycle (Danio rerio)
RAC2 binds effectors at the plasma membrane (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
pik3r3a [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A0R4IUJ2
Gene Names
pik3r3a
Reference Genes
BioGPS Gene:406311 pik3r3a
CTD Gene:406311 pik3r3a
ENSEMBL:ENSDARG00000103038
KEGG:dre:406311 pik3r3a
Monarch:406311 pik3r3a
NCBI Gene:406311 pik3r3a
UCSC:A0A0R4IUJ2 pik3r3a
Reference Transcript
RefSeq:NM_213038.2 pik3r3a
RefSeq:NM_001291329.1 pik3r3a
Other Identifiers
13078476
406311
A_15_P207341
A_15_P286046
CUST_7198_PI428451953
DRER27399
DRER54122
DRER54949
Dr.58.1.A1_at
ENSDART00000067358_1
ENSDART00000067358_2
GT_Xhyb_XM_005163656.1_273455
JP011516
JP011529
LOLO1555
LOLO1556
LOLS09366
MADDr01003121
NM_213038
ZV700S00005741
Participates
as a candidate of
PI3K regulatory subunits [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
as a component of
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
Other forms of this molecule
pik3r3a [cytosol]
Inferred From
PIK3R3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001278258.1
,
NP_998203.2
ENSEMBL
ENSDART00000167649
,
ENSDART00000160715
,
ENSDARP00000130273
,
ENSDARG00000103038
,
ENSDARP00000140757
ZFIN
ZDB-GENE-040426-1978
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
