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Activated FGFR3b homodimer [plasma membrane]
Stable Identifier
R-DRE-190380
Type
Complex
Species
Danio rerio
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR3:pY-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
FRS-mediated FGFR3 signaling (Danio rerio)
Activated FGFR3 binds FRS2 (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3 binds FRS3 (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3 phosphorylates FRS2 (Danio rerio)
Activated FGFR3:FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-8T-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3 phosphorylates FRS3 (Danio rerio)
Activated FGFR3:FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3 phosphorylates PPTN11 (Danio rerio)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:pFRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
PI-3K cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Phospholipase C-mediated cascade; FGFR3 (Danio rerio)
Activated FGFR3 binds PLCG1 (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
activated FGFR3:PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3 phosphorylates PLCG1 (Danio rerio)
activated FGFR3:PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
activated FGFR3:p-4Y-PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
SHC-mediated cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR3:pY-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
FGFR3 ligand binding and activation (Danio rerio)
FGFR3b ligand binding and activation (Danio rerio)
Autocatalytic phosphorylation of FGFR3b (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Danio rerio)
Activated FGFR3:FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-8T-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
CBL ubiquitinates FRS2 and FGFR3 (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR3:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
Activated FGFR bound to PI3K [cytosol] (Danio rerio)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Danio rerio)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
Activated FGFR bound to PI3K [cytosol] (Danio rerio)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Danio rerio)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR [plasma membrane] (Danio rerio)
Activated FGFR3b homodimer [plasma membrane] (Danio rerio)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
FGFR3b-binding FGFs [extracellular region]
(Danio rerio)
HS [extracellular region]
x 2
phospho-fgfr3 [plasma membrane]
(Danio rerio)
Participates
as a member of
Activated FGFR [plasma membrane] (Danio rerio)
Activated FGFR3 [plasma membrane] (Danio rerio)
as an output of
Autocatalytic phosphorylation of FGFR3b (Danio rerio)
Inferred From
Activated FGFR3b homodimer [plasma membrane]
(Homo sapiens)
© 2025
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