Reactome | LOC570661 [nucleoplasm]

LOC570661 [nucleoplasm]

Stable Identifier

R-DRE-181898-3

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

HIST1H2BK, B3DJF8

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Prophase (Danio rerio)
      - Condensation of Prophase Chromosomes (Danio rerio)
        
        CDK1 phosphorylates PHF8 (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PHF8 demethylates histone H4K20me1 (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PLK1 binds phosphorylated condensin II complex (Danio rerio)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PLK1 hyperphosphorylates Condensin II complex (Danio rerio)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        SETD8 monomethylates histone H4 (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular Senescence (Danio rerio)
    - Oxidative Stress Induced Senescence (Danio rerio)
      - PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Danio rerio)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

Chromatin organization (Danio rerio)

- Chromatin modifying enzymes (Danio rerio)
  - HDACs deacetylate histones (Danio rerio)
    - HDAC10 deacetylates histone (Danio rerio)
      - Core histone octamer [nucleoplasm] (Danio rerio)
        
        Histone H2A:H2B [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone HIST1H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
    - HDAC8 deacetylates histones (Danio rerio)
      - Core histone octamer [nucleoplasm] (Danio rerio)
        
        Histone H2A:H2B [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone HIST1H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- Epigenetic regulation of gene expression (Danio rerio)
  - Negative epigenetic regulation of rRNA expression (Danio rerio)
    - NoRC negatively regulates rRNA expression (Danio rerio)
      - MBD2 binds methylcytosine in chromatin (Danio rerio)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Danio rerio)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
  - PRC2 methylates histones and DNA (Danio rerio)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Danio rerio)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Danio rerio)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Danio rerio)
        
        PRC2 Core:Chromatin [nucleoplasm] (Danio rerio)
        
        Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
    - PRC2 recruits DNA methyltransferases (Danio rerio)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Danio rerio)
        
        PRC2 Core:Chromatin [nucleoplasm] (Danio rerio)
        
        Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - PRC2 Core:Chromatin [nucleoplasm] (Danio rerio)
        
        Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
    - PRC2 trimethylates histone H3 at lysine-27 (Danio rerio)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Danio rerio)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - PRC2:Chromatin [nucleoplasm] (Danio rerio)
        
        Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
    - Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)
      - Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - PRC2:Chromatin [nucleoplasm] (Danio rerio)
        
        Chromatin [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
- RNA Polymerase I Transcription (Danio rerio)
  - RNA Polymerase I Promoter Clearance (Danio rerio)
    - RNA Polymerase I Promoter Opening (Danio rerio)
      - UBF-1 Binds rDNA Promoter (Danio rerio)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Danio rerio)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional regulation by RUNX1 (Danio rerio)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Danio rerio)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Deubiquitination (Danio rerio)
    - Ub-specific processing proteases (Danio rerio)
      - USP3,SAGA deubiquitinate Histone H2A,H2B (Danio rerio)
        
        USP3,SAGA:Histone H2A,Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone H2A,Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone HIST1H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - USP49 deubiquitinates H2B (Danio rerio)
        
        USP49:Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Histone HIST1H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Nuclear Receptors (Danio rerio)
  - ESR-mediated signaling (Danio rerio)
    - Estrogen-dependent gene expression (Danio rerio)
      - ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Danio rerio)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Danio rerio)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm] (Danio rerio)
        
        Nucleosome [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Danio rerio)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases activate PKNs (Danio rerio)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Danio rerio)
        
        Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Danio rerio)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Danio rerio)
        
        Histone H2B [nucleoplasm] (Danio rerio)
        
        Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)
        
        LOC570661 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:B3DJF8

Gene Names

LOC570661

Reference Genes

BioGPS Gene:570661 LOC570661

ENSEMBL:ENSDARG00000114405

ENSEMBL:ENSDARG00000114405.1 LOC570661

KEGG Gene (Danio rerio):570661 LOC570661

Monarch:570661 LOC570661

NCBI Gene:570661 LOC570661

Reference Transcript

RefSeq:NM_001128759.1 LOC570661

Other Identifiers

13163221

13284024

13284026

570661

A_15_P156216

A_15_P631406

CUST_185_PI424165604

CUST_186_PI424165604

CUST_187_PI424165604

CUST_188_PI424165604

CUST_189_PI424165604

CUST_190_PI424165604

CUST_191_PI424165604

CUST_192_PI424165604

DRER06123

DRER09845

ENSDART00000073457_x_1

ENSDART00000073457_x_2

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0030527

GO:0043226

GO:0046982

GT_Spec_NM_001128759.1_296475

Participates

as a member of

Homologues of HIST1H2BK [nucleoplasm] (Danio rerio)

Other forms of this molecule

LOC570661 [nucleoplasm]

Inferred From

HIST1H2BM [nucleoplasm] (Homo sapiens)

HIST1H2BD [nucleoplasm] (Homo sapiens)

HIST1H2BH [nucleoplasm] (Homo sapiens)

H2BFS [nucleoplasm] (Homo sapiens)

HIST1H2BN [nucleoplasm] (Homo sapiens)

HIST1H2BC [nucleoplasm] (Homo sapiens)

HIST1H2BJ [nucleoplasm] (Homo sapiens)

HIST1H2BK [nucleoplasm] (Homo sapiens)

HIST1H2BL [nucleoplasm] (Homo sapiens)

HIST3H2BB [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001122231.1

ZFIN

ZDB-GENE-080723-3

Ensembl

ENSDARP00000067948, ENSDARG00000114405, ENSDART00000073457

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