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smurf2 [cytosol]
Stable Identifier
R-DRE-173537
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
SMURF2, A9JRZ0
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Polyubiquitination of substrate (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Release of E3 from polyubiquitinated substrate (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Deubiquitination (Danio rerio)
Ub-specific processing proteases (Danio rerio)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Danio rerio)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Danio rerio)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Danio rerio)
SMAD7:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Danio rerio)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Danio rerio)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by TGFB family members (Danio rerio)
Signaling by BMP (Danio rerio)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Danio rerio)
I-SMAD:SMURF [cytosol] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
I-SMAD:SMURF [cytosol] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Signaling by TGF-beta Receptor Complex (Danio rerio)
TGF-beta receptor signaling activates SMADs (Danio rerio)
Downregulation of TGF-beta receptor signaling (Danio rerio)
SMURF2 binds SMAD2 (Danio rerio)
SMAD2:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
SMAD2:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
PCP/CE pathway (Danio rerio)
Asymmetric localization of PCP proteins (Danio rerio)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Danio rerio)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
SMURF [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
TCF dependent signaling in response to WNT (Danio rerio)
Degradation of AXIN (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
AXIN:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
ub-AXIN:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
SMURF2 binds AXIN (Danio rerio)
AXIN:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
smurf2 [cytosol] (Danio rerio)
ub-AXIN:SMURF2 [cytosol] (Danio rerio)
smurf2 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A9JRZ0
Gene Names
smurf2
Reference Genes
BioGPS Gene:563633 smurf2
ENSEMBL:ENSDARG00000038067
KEGG Gene (Danio rerio):563633 smurf2
Monarch:563633 smurf2
NCBI Gene:563633 smurf2
Reference Transcript
RefSeq:NM_001114426.1 smurf2
Other Identifiers
13174462
563633
A_15_P101948
A_15_P118795
A_15_P499752
CJ014129
DRER07110
Dr.23203.1.A1_at
Dr.3801.1.A1_at
ENSDART00000055491
ENSDART00000055491_1
ENSDART00000055491_2
GT_Xhyb_XM_005171584.1_165336
LOLS07004
XM_684932
XM_704272
ZV700S00003900
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Danio rerio)
ub-AXIN:SMURF2 [cytosol] (Danio rerio)
AXIN:SMURF2 [cytosol] (Danio rerio)
SMAD7:SMURF2 [cytosol] (Danio rerio)
SMAD2:SMURF2 [cytosol] (Danio rerio)
as an output of
Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
as an input of
SMURF2 binds AXIN (Danio rerio)
SMURF2 binds SMAD2 (Danio rerio)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
SMURF [cytosol] (Danio rerio)
Other forms of this molecule
smurf2 [nucleoplasm]
Inferred From
SMURF2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001107898.1
IntEnz
2.3.2.26
ZFIN
ZDB-GENE-030131-1830
Ensembl
ENSDARP00000055490
,
ENSDARG00000038067
,
ENSDART00000055491
PRO
A9JRZ0
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