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phospho-map2k2a [cytosol]
Stable Identifier
R-DRE-169292
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
p-S222,S226-MAP2K2, Q1LY62
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dissociation of RAS:RAF complex (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Negative feedback regulation of MAPK pathway (Danio rerio)
Activated MAPKs phosphorylate MAP2K1 (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
RAF activation (Danio rerio)
Phosphorylation of RAF (Danio rerio)
RAF activating kinases [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
Frs2-mediated activation (Danio rerio)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol] (Danio rerio)
phospho-map2k2a [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q1LY62
Gene Names
map2k2a
Reference Genes
BioGPS Gene:563181 map2k2a
CTD Gene:563181 map2k2a
ENSEMBL:ENSDARG00000006609
KEGG Gene (Danio rerio):563181 map2k2a
Monarch:563181 map2k2a
NCBI Gene:563181 map2k2a
Reference Transcript
RefSeq:NM_001037391.2 map2k2a
Other Identifiers
13128180
563181
A_15_P105172
A_15_P109208
A_15_P112231
A_15_P148956
A_15_P466355
A_15_P626596
CJ009221
CJ009222
CJ009223
CJ012881
CJ013066
CUST_17807_PI428451953
CUST_9970_PI428451958
DRER01152
Dr.8.3.A1_at
ENSDART00000010048
ENSDART00000010048_1
ENSDART00000010048_2
GO:0000165
GO:0000166
GO:0000187
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0005524
GO:0006464
GO:0006468
GO:0007165
GO:0008150
GO:0016301
GO:0016310
GO:0043167
GT_Spec_NM_001037391.2_271445
JP009619
JP009620
JP009621
LOL01496
LOL01497
LOL02004
LOL04512
LOL04513
LOL04514
LOL04515
LOL04516
LOL04517
LOL04518
LOL04519
LOL04520
LOL04521
LOL04523
LOL04524
LOL05311
LOL05312
LOLS12946
MADDr01005675
NM_001037391
OTTDART00000011786
Participant Of
hasComponent
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
p-S222,S226 MAP2K2 dimer [cytosol]
Other forms of this molecule
map2k2a [cytosol]
phospho-map2k2a [cytosol]
Inferred From
p-S222,S226-MAP2K2 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001032468.2
Ensembl
ENSDARG00000006609
,
ENSDART00000010048
,
ENSDARP00000014914
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