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cbl [cytosol]
Stable Identifier
R-DRE-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
CBL, Q5U376
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Interleukin-6 family signaling (Danio rerio)
Interleukin-6 signaling (Danio rerio)
PTPN11 binds CBL (Danio rerio)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Danio rerio)
PTK6 phosphorylates CBL (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR downregulation (Danio rerio)
Binding of CBL to EGFR (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
CBL binds to GRB2 (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
CBL ubiquitinates Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Localization of CBL:GRB2 to the membrane (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylation of CBL (EGFR:CBL) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Sprouty lures CBL away from EGFR (Danio rerio)
CBL:SPRY1/2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
SPRY2 binds CBL (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Negative regulation of FGFR2 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
SPRY2 binds CBL (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
SPRY2 binds CBL (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Negative regulation of FGFR4 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
SPRY2 binds CBL (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
Negative regulation of MET activity (Danio rerio)
MET phosphorylates CBL (Danio rerio)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Regulation of KIT signaling (Danio rerio)
Recruitment of CBL to KIT (Danio rerio)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
Signaling by TGFB family members (Danio rerio)
Signaling by TGF-beta Receptor Complex (Danio rerio)
TGF-beta receptor signaling activates SMADs (Danio rerio)
CBL binds TGFBR2 (Danio rerio)
TGFBR2:CBL [plasma membrane] (Danio rerio)
cbl [cytosol] (Danio rerio)
cbl [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q5U376
Gene Names
cbl
Reference Genes
BioGPS Gene:492364 cbl
ENSEMBL:ENSDARG00000009958
KEGG Gene (Danio rerio):492364 cbl
Monarch:492364 cbl
NCBI Gene:492364 cbl
Reference Transcript
RefSeq:NM_001007330.1 cbl
Participates
as an input of
PTPN11 binds CBL (Danio rerio)
Sprouty lures CBL away from EGFR (Danio rerio)
Binding of CBL to EGFR (Danio rerio)
PTK6 phosphorylates CBL (Danio rerio)
SPRY2 binds CBL (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
CBL binds to GRB2 (Danio rerio)
Recruitment of CBL to KIT (Danio rerio)
CBL binds TGFBR2 (Danio rerio)
as a component of
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Danio rerio)
CBL:SPRY1/2 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
CBL:GRB2 [cytosol] (Danio rerio)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
TGFBR2:CBL [plasma membrane] (Danio rerio)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Other forms of this molecule
phospho-cbl [plasma membrane]
phospho-cbl [cytosol]
phospho-cbl [cytosol]
phospho-cbl [cytosol]
phospho-cbl [cytosol]
Inferred From
CBL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001007331.1
ZFIN
ZDB-GENE-041114-207
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