Reactome | Dmel\CG12106 [cytosol]

Dmel\CG12106 [cytosol]

Stable Identifier

R-DME-8955113

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

COMMD3, Q9I7W2

Locations in the PathwayBrowser

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Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Neddylation (Drosophila melanogaster)
    - 26S proteasome degrades HIFalpha (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        COMMDs [cytosol] (Drosophila melanogaster)
        
        Dmel\CG12106 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9I7W2

Gene Names

Dmel\CG12106

Reference Genes

BioGPS Gene:31856 Dmel\CG12106

ENSEMBL:FBgn0030100

Flybase:FBgn0030100

KEGG Gene (Drosophila melanogaster):Dmel_CG12106 Dmel\CG12106

Monarch:31856 Dmel\CG12106

NCBI Gene:31856 Dmel\CG12106

UCSC:Q9I7W2 Dmel\CG12106

Reference Transcript

RefSeq:NM_132308.2 Dmel\CG12106

Other Identifiers

151907_at

1630523_at

31856

GO:0003674

GO:0005575

GO:0006814

GO:0008150

Participates

as a candidate of

COMMDs [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Dmel\CG12106 [nucleoplasm]

Dmel\CG12106 [extracellular region]

Dmel\CG12106 [ficolin-1-rich granule lumen]

Inferred From

COMMD3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_572536.1

Flybase

FBgn0030100

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21461	2	SIAH2 [cytosol] (R-DME-374566) SIAH1 [cytosol] (R-DME-374563)	0.488	2

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