Reactome | PDHA2 [mitochondrial matrix]

PDHA2

Stable Identifier

R-DME-8953513-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

mitochondrial matrix

Synonyms

Q7YU05

Locations in the PathwayBrowser

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Metabolism (Drosophila melanogaster)

- Metabolism of amino acids and derivatives (Drosophila melanogaster)
  - Glyoxylate metabolism and glycine degradation (Drosophila melanogaster)
    - LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)
      - DHs [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - lipoylated DHs [mitochondrial matrix] (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
- The citric acid (TCA) cycle and respiratory electron transport (Drosophila melanogaster)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Drosophila melanogaster)
    - Pyruvate metabolism (Drosophila melanogaster)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
        
        PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - Signaling by Retinoic Acid (Drosophila melanogaster)
    - PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)
      - lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7YU05

Reference Genes

BioGPS Gene:31406

dbSNP Gene:31406

ENSEMBL:FBgn0028325

Flybase:FBgn0028325

Monarch:31406

NCBI Gene:31406

UCSC:Q7YU05

Reference Transcript

RefSeq:NM_167019.2

Other Identifiers

00010+1.2.4.1

00020+1.2.4.1

00620+1.2.4.1

153790_at

1635253_a_at

AAF45976.1

AAF45978.1

AAN09129.1

BT010068

BT125860

EntrezGene:31406

F6J1A7

FBgn0028325

FBpp0070676

FBpp0070678

FBtr0070708

FBtr0070710

IPR001017

IPR017597

IPR029061

NM_131953.5

NM_167017.3

NM_167018.2

NM_167019.2

NP_572181.4

NP_726946.1

NP_726947.1

PF00676

UPI000002A188

UPI000002A189

Participant Of

hasMember

Homologues of PDHA2 [mitochondrial matrix]

Other forms of this molecule

PDHA1 [mitochondrial matrix]

Inferred From

PDHA2 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_726947.1

Flybase

FBgn0028325

BRENDA (Drosophila melanogaster)

1.2.4.1