Reactome | PDHA2 [mitochondrial matrix]

PDHA2 [mitochondrial matrix]

Stable Identifier

R-DME-8953513-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

mitochondrial matrix

Synonyms

Q9W4H4

Locations in the PathwayBrowser

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Metabolism (Drosophila melanogaster)

- Metabolism of amino acids and derivatives (Drosophila melanogaster)
  - Glyoxylate metabolism and glycine degradation (Drosophila melanogaster)
    - LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs (Drosophila melanogaster)
      - DHs [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - lipoylated DHs [mitochondrial matrix] (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
- The citric acid (TCA) cycle and respiratory electron transport (Drosophila melanogaster)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Drosophila melanogaster)
    - Pyruvate metabolism (Drosophila melanogaster)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
        
        PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDP dephosphorylates p-lipo-PDH (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - lipo-PDH decarboxylates PYR to Ac-CoA (Drosophila melanogaster)
        
        lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - Signaling by Retinoic Acid (Drosophila melanogaster)
    - PDK isoforms phosphorylate lipo-PDH (Drosophila melanogaster)
      - lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
      - p-lipo-PDH [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Drosophila melanogaster)
        
        PDH E1 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA1,2 [mitochondrial matrix] (Drosophila melanogaster)
        
        Homologues of PDHA2 [mitochondrial matrix] (Drosophila melanogaster)
        
        PDHA2 [mitochondrial matrix] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W4H4

Reference Genes

BioGPS Gene:31407

dbSNP Gene:31407

ENSEMBL:FBgn0029722

Flybase:FBgn0029722

KEGG Gene (Drosophila melanogaster):Dmel_CG7024

Monarch:31407

NCBI Gene:31407

UCSC:Q9W4H4

Reference Transcript

RefSeq:NM_131954.1

Other Identifiers

00010+1.2.4.1

00020+1.2.4.1

00620+1.2.4.1

144488_at

1629402_at

7227.FBpp0070680

AAF45979.1

BT010310

EntrezGene:31407

FBgn0029722

FBpp0070680

FBtr0070712

GO:0003674

GO:0004739

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0006086

GO:0006790

GO:0008150

GO:0009058

GO:0016491

GO:0016624

GO:0034641

GO:0043226

GO:0043231

GO:0044281

GO:0051186

GO:0055114

IPR001017

IPR017597

IPR029061

NM_131954.1

NP_572182.1

PF00676

UPI000007B638

Participant Of

hasMember

Homologues of PDHA2 [mitochondrial matrix]

Inferred From

PDHA2 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_572182.1

Flybase

FBgn0029722