Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
kappaB-Ras [cytosol]
Stable Identifier
R-DME-8952686
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
NKIRAS1, Q9V4L4
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Cytosolic sensors of pathogen-associated DNA (Drosophila melanogaster)
ZBP1(DAI) mediated induction of type I IFNs (Drosophila melanogaster)
RIP-mediated NFkB activation via ZBP1 (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Drosophila melanogaster)
TRAF6 mediated NF-kB activation (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
kappaB-Ras [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V4L4
Gene Names
kappaB-Ras
Reference Genes
BioGPS Gene:35667 kappaB-Ras
ENSEMBL:FBgn0040513
FlyBase:FBgn0040513
KEGG:dme:Dmel_CG1669 kappaB-Ras
Monarch:35667 kappaB-Ras
NCBI Gene:35667 kappaB-Ras
UCSC:Q9V4L4 kappaB-Ras
Reference Transcript
RefSeq:NM_001273841.1 kappaB-Ras
RefSeq:NM_136434.5 kappaB-Ras
RefSeq:NM_001144141.3 kappaB-Ras
Other Identifiers
146741_at
153461_at
1630406_at
1636217_at
35667
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0016787
GO:0032484
GO:0032794
GO:0043124
GO:0106137
This entity regulates
Negatively
Active IKK Complex phosphorylates NF-kappa-B inhibitor
(Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor
(Drosophila melanogaster)
Other forms of this molecule
kappaB-Ras [cytosol]
Inferred From
NKIRAS [cytosol]
(Homo sapiens)
NKIRAS1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_610278.1
,
NP_001137613.1
,
NP_001260770.1
ENSEMBL
FBgn0040513
,
FBtr0089002
,
FBpp0088074
,
FBtr0299801
,
FBtr0336926
,
FBpp0307863
,
FBpp0289079
FlyBase
FBgn0040513
PRO
Q9V4L4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q4V6I0 Q4V6I0
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text