Reactome | EG:22E5.10 [clathrin-coated endocytic vesicle membrane]

EG:22E5.10 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DME-8869071-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

AGTR1, Q9W533

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EG:22E5.10 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W533

Gene Names

EG:22E5.10

Reference Genes

BioGPS Gene:31169 EG:22E5.10

ENSEMBL:FBgn0025632

Flybase:FBgn0025632

Monarch:31169 EG:22E5.10

NCBI Gene:31169 EG:22E5.10

UCSC:Q9W533 EG:22E5.10

Reference Transcript

RefSeq:NM_130615.3 EG:22E5.10

Other Identifiers

31169

GO:0003674

GO:0004930

GO:0005575

GO:0007165

GO:0007186

GO:0008150

GO:0016020

GO:0016021

Participates

as a member of

Homologues of AGTR1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Other forms of this molecule

EG:22E5.10 [plasma membrane]

Inferred From

AGTR1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_569971.3

Flybase

FBgn0025632

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