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lap [cytosol]
Stable Identifier
R-DME-8867593
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
PICALM, Q9VI75
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
PICALM binds R-SNAREs (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
lap [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VI75
Gene Names
lap
Reference Genes
BioGPS Gene:40863 lap
ENSEMBL:FBgn0086372
Flybase:FBgn0086372
KEGG Gene (Drosophila melanogaster):Dmel_CG2520 lap
Monarch:40863 lap
NCBI Gene:40863 lap
Reference Transcript
RefSeq:NM_079528.3 lap
Other Identifiers
149429_at
1626943_at
1636846_at
40863
GO:0000149
GO:0005543
GO:0005545
GO:0005546
GO:0005794
GO:0005886
GO:0005905
GO:0006897
GO:0006898
GO:0006900
GO:0007268
GO:0007270
GO:0008021
GO:0008289
GO:0016020
GO:0016185
GO:0016192
GO:0023052
GO:0030136
GO:0030276
GO:0031410
GO:0032050
GO:0042331
GO:0043226
GO:0048268
GO:0048489
GO:0061024
GO:0065003
GO:0072583
GO:0098894
GO:0150007
GO:2000370
Participates
as a component of
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
as an input of
PICALM binds R-SNAREs (Drosophila melanogaster)
Other forms of this molecule
lap [cytosol]
lap [Golgi membrane]
lap [cytoplasmic vesicle membrane]
Inferred From
PICALMs [cytosol]
(Homo sapiens)
PICALM [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524252.2
Flybase
FBgn0086372
PRO
Q9VI75
PDB
1HX8
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