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eff [cytosol]
Stable Identifier
R-DME-8864160
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Ub-C85-UBE2D1, P25867
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Protein ubiquitination (Drosophila melanogaster)
E3 ubiquitin ligases ubiquitinate target proteins (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Drosophila melanogaster)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)
Ub:E2 (UBA1 substrate) [cytosol] (Drosophila melanogaster)
Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Protein localization (Drosophila melanogaster)
Peroxisomal protein import (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
TNF signaling (Drosophila melanogaster)
Regulation of TNFR1 signaling (Drosophila melanogaster)
MIB2 binds CFLAR (Drosophila melanogaster)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
MIB2 ubiquitinates CFLAR (Drosophila melanogaster)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Drosophila melanogaster)
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)
eff [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P25867 eff
Gene Names
eff, UbcD1, CG7425
Chain
chain:1-147
Reference Genes
BioGPS Gene:41785 eff
KEGG Gene (Drosophila melanogaster):Dmel_CG7425 eff
Monarch:41785 eff
NCBI Gene:41785 eff
Reference Transcript
RefSeq:NM_001275649.1 eff
RefSeq:NM_169601.2 eff
RefSeq:NM_001275650.1 eff
Other Identifiers
143638_at
1636436_at
41785
GO:0000151
GO:0000166
GO:0000209
GO:0000278
GO:0001745
GO:0001751
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005829
GO:0006511
GO:0007049
GO:0007140
GO:0016322
GO:0016567
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030718
GO:0031145
GO:0031625
GO:0031647
GO:0036211
GO:0043226
GO:0045676
GO:0045879
GO:0048132
GO:0048856
GO:0051276
GO:0051301
GO:0051321
GO:0061057
GO:0061631
GO:0097039
GO:0098542
GO:0140013
GO:0140096
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Drosophila melanogaster)
as an output of
MIB2 ubiquitinates CFLAR (Drosophila melanogaster)
MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)
as a component of
Ub:UBE2D1,2,3 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
EFF [cytosol]
eff [nucleoplasm]
eff [cytosol]
Inferred From
Ub-C85-UBE2D1,2,3 [cytosol]
(Homo sapiens)
Ub-C85-UBE2D1 [cytosol]
(Homo sapiens)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85 (in Homo sapiens)
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_731941.1
,
NP_001262578.1
,
NP_001262579.1
Flybase
FBgn0011217
PRO
P25867
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A1Z9I6
1
anon-EST:GressD1 [cytosol]
(R-DME-975976)
0.621
3
UniProt:Q9VHI7
2
Iru [cytosol]
(R-DME-8850904)
Iru [cytosol]
(R-DME-8851642)
0.488
2
UniProt:Q9VNB2 Q9VNB2
0.488
2
UniProt:Q8T3Y0
1
SIAH2 [cytosol]
(R-DME-374566-2)
0.488
2
UniProt:Q7JUV6 Q7JUV6
0.488
2
UniProt:Q9VP20
2
phospho-Mkrn1 [cytosol]
(R-DME-8948758)
Mkrn1 [cytosol]
(R-DME-976042)
0.488
2
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