Reactome | Dmel\CG7565 [plasma membrane]

Dmel\CG7565 [plasma membrane]

Stable Identifier

R-DME-8864136

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

KIAA0319, Q9VSC9

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)
        
        Dmel\CG7565 [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VSC9

Gene Names

Dmel\CG7565

Reference Genes

BioGPS Gene:38893 Dmel\CG7565

ENSEMBL:FBgn0035833

FlyBase:FBgn0035833

KEGG:dme:Dmel_CG7565 Dmel\CG7565

Monarch:38893 Dmel\CG7565

NCBI Gene:38893 Dmel\CG7565

UCSC:Q9VSC9 Dmel\CG7565

Reference Transcript

RefSeq:NM_139914.4 Dmel\CG7565

Other Identifiers

152863_at

1625569_at

38893

GO:0001764

GO:0003674

GO:0005886

GO:0016020

GO:0031410

GO:0043226

GO:0048870

Participates

as a component of

KIAA0319 dimer [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

Dmel\CG7565 [clathrin-coated endocytic vesicle membrane]

Inferred From

KIAA0319 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

FBgn0035833, FBtr0076738, FBpp0076461

FlyBase

FBgn0035833

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