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phospho-p-7Y,Y1112-ERBB2 [plasma membrane]
Stable Identifier
R-DME-8864079
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
P04412
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MATK [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
ERBB2 Regulates Cell Motility (Drosophila melanogaster)
MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Drosophila melanogaster)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
phospho-p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P04412
Reference Genes
BioGPS Gene:37455
ENSEMBL:FBgn0003731
FlyBase:FBgn0003731
KEGG Gene (Drosophila melanogaster):Dmel_CG10079
Monarch:37455
NCBI Gene:37455
Reference Transcript
RefSeq:NM_057411.4
Other Identifiers
142966_at
151735_at
1633948_a_at
37455
GO:0000003
GO:0000166
GO:0000278
GO:0001654
GO:0001742
GO:0001751
GO:0002009
GO:0003013
GO:0003015
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005006
GO:0005515
GO:0005524
GO:0005886
GO:0006468
GO:0007163
GO:0007169
GO:0007173
GO:0007298
GO:0007309
GO:0007367
GO:0007390
GO:0007391
GO:0007395
GO:0007422
GO:0007426
GO:0007431
GO:0007443
GO:0007444
GO:0007455
GO:0007472
GO:0007474
GO:0007476
GO:0007477
GO:0007479
GO:0007482
GO:0008071
GO:0008284
GO:0008340
GO:0008355
GO:0008406
GO:0008586
GO:0009792
GO:0009880
GO:0009925
GO:0010628
GO:0010629
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016318
GO:0016324
GO:0016330
GO:0016333
GO:0016740
GO:0022008
GO:0022414
GO:0023052
GO:0030031
GO:0030154
GO:0030381
GO:0030718
GO:0035088
GO:0035149
GO:0035159
GO:0035160
GO:0035225
GO:0035230
GO:0035277
GO:0035309
GO:0035310
GO:0036211
GO:0038127
GO:0042060
GO:0042127
GO:0042327
GO:0042675
GO:0043066
GO:0043235
GO:0043703
GO:0045198
GO:0045465
GO:0045572
GO:0046530
GO:0046673
GO:0046843
GO:0048149
GO:0048546
GO:0048749
GO:0048856
GO:0048865
GO:0048870
GO:0050877
GO:0051781
GO:0060089
GO:0061331
GO:0070374
GO:0090303
GO:0098590
GO:0140096
GO:1903688
GO:2000134
GO:2001234
Participates
as a component of
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
phospho-ERBB4jmAcyt1s80 [mitochondrial matrix]
phospho-ERBB4jmAcyt2s80 [mitochondrial matrix]
phospho-ERBB4jmAcyt2s80 [nucleoplasm]
phospho-ERBB4jmAcyt1s80 [nucleoplasm]
phospho-ERBB4jmAcyt2s80 [cytosol]
phospho-ERBB4jmAcyt2m80 [plasma membrane]
phospho-ERBB4jmAcyt1m80 [plasma membrane]
phospho-ERBB4jmAcyt1s80 [cytosol]
phospho-p-4Y-EGFR [plasma membrane]
phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
ERBB2 [plasma membrane]
ERBB3-1 [plasma membrane]
phospho-p-Y877-ERBB2 [plasma membrane]
EGFR [plasma membrane]
phospho-p-Y1086,Y1101-EGFR [plasma membrane]
phospho-p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane]
ERBB4 JM-A CYT-1 isoform [plasma membrane]
ERBB4 JM-B CYT-1 isoform [plasma membrane]
ERBB4 JM-A CYT-2 isoform [plasma membrane]
phospho-p-Y-ERBB2 [plasma membrane]
phospho-p-Y,Y877-ERBB2 [plasma membrane]
phospho-p-10Y-ERBB3-1 [plasma membrane]
phospho-p-6Y-EGFR [plasma membrane]
phospho-p-6Y,Y1112-ERBB2 [plasma membrane]
phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane]
phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane]
phospho-p-7Y-ERBB2 [plasma membrane]
phospho-p-6Y-ERBB2 [plasma membrane]
Inferred From
p-7Y,Y1112-ERBB2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1023 (in Homo sapiens)
Coordinate
1023
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1112 (in Homo sapiens)
Coordinate
1112
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1139 (in Homo sapiens)
Coordinate
1139
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1196 (in Homo sapiens)
Coordinate
1196
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1221 (in Homo sapiens)
Coordinate
1221
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1222 (in Homo sapiens)
Coordinate
1222
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1248 (in Homo sapiens)
Coordinate
1248
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 877 (in Homo sapiens)
Coordinate
877
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_476759.1
Flybase
FBgn0003731
IntEnz
2.7.10.1
PRO
P04412
PDB
3I2T
,
3LTG
,
3LTF
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01083 SPITZ
0.696
5
UniProt:O46034 O46034
0.534
2
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