Reactome | Dmel\CG17754 [cytosol]

Dmel\CG17754 [cytosol]

Stable Identifier

R-DME-8863223

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

KLHL5, Q7K0L2

Locations in the PathwayBrowser

Expand all

Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
    - Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
      - Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
      - Polyubiquitination of substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
      - Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
      - Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
        
        BTB proteins [cytosol] (Drosophila melanogaster)
        
        Dmel\CG17754 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7K0L2

Gene Names

Dmel\CG17754

Reference Genes

BioGPS Gene:31873 Dmel\CG17754

ENSEMBL:FBgn0030114

Flybase:FBgn0030114

Monarch:31873 Dmel\CG17754

NCBI Gene:31873 Dmel\CG17754

UCSC:Q7K0L2 Dmel\CG17754

Reference Transcript

Other Identifiers

1628712_at

1638327_a_at

31873

GO:0003779

GO:0005515

GO:0008092

GO:0016567

GO:0036211

Participates

as a member of

BTB proteins [cytosol] (Drosophila melanogaster)

Inferred From

KLHL5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_572549.2, NP_727331.1

Flybase

FBgn0030114

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