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MRN [nucleoplasm]
Stable Identifier
R-DME-75164
Type
Complex
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
DNA Damage/Telomere Stress Induced Senescence (Drosophila melanogaster)
KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN activates ATM (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex binds DNA double strand breaks (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex binds shortened telomeres (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
DNA Double Strand Break Response (Drosophila melanogaster)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
ATM phosphorylates NBN (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Sensing of DNA Double Strand Breaks (Drosophila melanogaster)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN activates ATM (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex binds DNA double strand breaks (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
MRN [nucleoplasm] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
mre11 [nucleoplasm]
(Drosophila melanogaster)
nbs [nucleoplasm]
(Drosophila melanogaster)
RAD50 [nucleoplasm]
(Drosophila melanogaster)
Participates
as a component of
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm] (Drosophila melanogaster)
as an input of
MRN complex binds shortened telomeres (Drosophila melanogaster)
MRN complex binds DNA double strand breaks (Drosophila melanogaster)
as an output of
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)
Inferred From
MRN [nucleoplasm]
(Homo sapiens)
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