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Shc [cytosol]
Stable Identifier
R-DME-74680
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
SHC1, Q9V3C8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
SHC1 events in EGFR signaling (Drosophila melanogaster)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
SHC1 phosphorylation by phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Signaling by ERBB4 (Drosophila melanogaster)
SHC1 events in ERBB4 signaling (Drosophila melanogaster)
Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)
SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)
SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
Shc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3C8
Gene Names
Shc
Reference Genes
BioGPS Gene:44052 Shc
CTD Gene:44052 Shc
ENSEMBL:FBgn0015296
Flybase:FBgn0015296
KEGG Gene (Drosophila melanogaster):Dmel_CG3715 Shc
Monarch:44052 Shc
NCBI Gene:44052 Shc
UCSC:Q9V3C8 Shc
Reference Transcript
RefSeq:NM_079944.3 Shc
Other Identifiers
143792_at
1623967_at
44052
GO:0001751
GO:0002376
GO:0005154
GO:0005886
GO:0007163
GO:0007169
GO:0007173
GO:0007298
GO:0007362
GO:0007426
GO:0007427
GO:0007474
GO:0008069
GO:0008078
GO:0008293
GO:0008543
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030971
GO:0035011
GO:0035556
GO:0048010
GO:0048856
GO:0048870
GO:0051179
GO:0098542
GO:1904263
GO:1905815
Participates
as an input of
Activated integrin alphaIIb beta3 binds SHC1 (Drosophila melanogaster)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)
SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Drosophila melanogaster)
as a component of
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Drosophila melanogaster)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Drosophila melanogaster)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Drosophila melanogaster)
SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [plasma membrane]
phospho-Shc [plasma membrane]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Inferred From
SHC1 [cytosol]
(Homo sapiens)
SHC1-1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524683.2
Flybase
FBgn0015296
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VQ77 Q9VQ77
0.488
2
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