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Trx-2 [cytosol]
Stable Identifier
R-DME-73668
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
2xHC-TXN, Q9V429
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Oxidative Stress Induced Senescence (Drosophila melanogaster)
ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Drosophila melanogaster)
Inflammasomes (Drosophila melanogaster)
The NLRP3 inflammasome (Drosophila melanogaster)
ROS oxidize thioredoxin (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Protein repair (Drosophila melanogaster)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)
Trx-2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V429
Gene Names
Trx-2
Reference Genes
BioGPS Gene:34281 Trx-2
ENSEMBL:FBgn0040070
Flybase:FBgn0040070
KEGG Gene (Drosophila melanogaster):Dmel_CG31884 Trx-2
Monarch:34281 Trx-2
NCBI Gene:34281 Trx-2
UCSC:Q9V429 Trx-2
Reference Transcript
RefSeq:NM_164863.3 Trx-2
RefSeq:NM_078802.4 Trx-2
Other Identifiers
141539_at
1629426_s_at
34281
GO:0003824
GO:0005634
GO:0006979
GO:0008340
GO:0015035
GO:0015036
GO:0015038
GO:0016491
GO:0043226
GO:0045454
GO:0050832
GO:0098542
GO:0140096
Participates
as an output of
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
ROS oxidize thioredoxin (Drosophila melanogaster)
ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)
Other forms of this molecule
Trx-2 [cytosol]
Inferred From
2xHC-TXN [cytosol]
(Homo sapiens)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 32 and 35 (in Homo sapiens)
Coordinate
32
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
NP_723475.1
,
NP_523526.1
Flybase
FBgn0040070
PRO
Q9V429
PDB
1XWC
,
1XW9
,
1XWA
,
1XWB
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7K4H4
1
RIOX1 [nucleoplasm]
(R-DME-3215035)
0.488
2
UniProt:Q9VFP6
1
Ipp [cytosol]
(R-DME-1604575)
0.488
2
UniProt:Q9VMU4 RL37A
0.488
2
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