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26S proteasome [cytosol]
Stable Identifier
R-DME-68819
Type
Complex
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
p53-Independent G1/S DNA damage checkpoint (Drosophila melanogaster)
p53-Independent DNA Damage Response (Drosophila melanogaster)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Drosophila melanogaster)
Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Separation of Sister Chromatids (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Drosophila melanogaster)
Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Securin (Drosophila melanogaster)
Degradation of multiubiquitinated Securin (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Ubiquitin-dependent degradation of Cyclin D (Drosophila melanogaster)
Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
CDK-mediated phosphorylation and removal of Cdc6 (Drosophila melanogaster)
Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Drosophila melanogaster)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing-Cross presentation (Drosophila melanogaster)
Cross-presentation of soluble exogenous antigens (endosomes) (Drosophila melanogaster)
Proteasomal clevage of exogenous antigen (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Proteasomal cleavage of substrate (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
Ubiquitinated IkB is degraded (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
TNFR2 non-canonical NF-kB pathway (Drosophila melanogaster)
NIK-->noncanonical NF-kB signaling (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Dectin-1 mediated noncanonical NF-kB signaling (Drosophila melanogaster)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of polyamines (Drosophila melanogaster)
Regulation of ornithine decarboxylase (ODC) (Drosophila melanogaster)
26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Drosophila melanogaster)
AUF1:mRNA complex is destroyed (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
UCH proteinases (Drosophila melanogaster)
ADRM1 binds 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome:UCHL5 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome:USP14 [cytosol] (Drosophila melanogaster)
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
26S proteasome degrades HIFalpha (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
Regulation of RAS by GAPs (Drosophila melanogaster)
NF1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog 'off' state (Drosophila melanogaster)
Degradation of GLI1 by the proteasome (Drosophila melanogaster)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
GLI3 is processed to GLI3R by the proteasome (Drosophila melanogaster)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
Hh C-terminal fragments are degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
PCP/CE pathway (Drosophila melanogaster)
Asymmetric localization of PCP proteins (Drosophila melanogaster)
PRICKLE1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Degradation of AXIN (Drosophila melanogaster)
Ubiquitinated AXIN is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Degradation of DVL (Drosophila melanogaster)
Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)
26S proteasome [cytosol] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Ghost homologue of PSMB1 [cytosol]
(Drosophila melanogaster)
Ghost homologue of PSMD10 [cytosol]
(Drosophila melanogaster)
Ghost homologue of PSME4 [cytosol]
(Drosophila melanogaster)
Ghost homologue of SEM1 [cytosol]
(Drosophila melanogaster)
Homologues of PSMA8 [cytosol]
(Drosophila melanogaster)
Homologues of PSMB10 [cytosol]
(Drosophila melanogaster)
Homologues of PSMB11 [cytosol]
(Drosophila melanogaster)
Homologues of PSMB8 [cytosol]
(Drosophila melanogaster)
PI31 [cytosol]
(Drosophila melanogaster)
Prosalpha1 [cytosol]
(Drosophila melanogaster)
Prosalpha2 [cytosol]
(Drosophila melanogaster)
Prosalpha3 [cytosol]
(Drosophila melanogaster)
Prosalpha4 [cytosol]
(Drosophila melanogaster)
Prosalpha5 [cytosol]
(Drosophila melanogaster)
Prosalpha6 [cytosol]
(Drosophila melanogaster)
Prosalpha7 [cytosol]
(Drosophila melanogaster)
Prosbeta1 [cytosol]
(Drosophila melanogaster)
Prosbeta1 [cytosol]
(Drosophila melanogaster)
Prosbeta2 [cytosol]
(Drosophila melanogaster)
Prosbeta3 [cytosol]
(Drosophila melanogaster)
Prosbeta4 [cytosol]
(Drosophila melanogaster)
Prosbeta5 [cytosol]
(Drosophila melanogaster)
Prosbeta7 [cytosol]
(Drosophila melanogaster)
PSMC1 [cytosol]
(Drosophila melanogaster)
PSMC5 [cytosol]
(Drosophila melanogaster)
PSMD14 [cytosol]
(Drosophila melanogaster)
PSMD5 [cytosol]
(Drosophila melanogaster)
PSMD9 [cytosol]
(Drosophila melanogaster)
REG [cytosol]
(Drosophila melanogaster)
REG [cytosol]
(Drosophila melanogaster)
REG [cytosol]
(Drosophila melanogaster)
Rpn1 [cytosol]
(Drosophila melanogaster)
Rpn10 [cytosol]
(Drosophila melanogaster)
Rpn12 [cytosol]
(Drosophila melanogaster)
Rpn2 [cytosol]
(Drosophila melanogaster)
Rpn3 [cytosol]
(Drosophila melanogaster)
Rpn5 [cytosol]
(Drosophila melanogaster)
Rpn6 [cytosol]
(Drosophila melanogaster)
Rpn7 [cytosol]
(Drosophila melanogaster)
Rpn8 [cytosol]
(Drosophila melanogaster)
Rpn9 [cytosol]
(Drosophila melanogaster)
Rpt1 [cytosol]
(Drosophila melanogaster)
Rpt3 [cytosol]
(Drosophila melanogaster)
Rpt4 [cytosol]
(Drosophila melanogaster)
Rpt5 [cytosol]
(Drosophila melanogaster)
Participates
as a component of
ADRM1:26S proteasome [cytosol] (Drosophila melanogaster)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Drosophila melanogaster)
as an input of
ADRM1 binds 26S proteasome (Drosophila melanogaster)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Drosophila melanogaster)
as an output of
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)
Inferred From
26S proteasome [cytosol]
(Homo sapiens)
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