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PolE2 [nucleoplasm]
Stable Identifier
R-DME-68482
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
POLE2, Q9VRQ7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA replication initiation (Drosophila melanogaster)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
PCNA-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA Damage Bypass (Drosophila melanogaster)
Recognition of DNA damage by PCNA-containing replication complex (Drosophila melanogaster)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Drosophila melanogaster)
Termination of translesion DNA synthesis (Drosophila melanogaster)
POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Dual Incision in GG-NER (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in GG-NER (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
POLD,POLE [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
DNA Replication Pre-Initiation (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA replication initiation (Drosophila melanogaster)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon:origin complex [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
PolE2 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VRQ7
Gene Names
PolE2
Reference Genes
BioGPS Gene:38661 PolE2
ENSEMBL:FBgn0035644
Flybase:FBgn0035644
KEGG Gene (Drosophila melanogaster):Dmel_CG10489 PolE2
Monarch:38661 PolE2
NCBI Gene:38661 PolE2
UCSC:Q9VRQ7 PolE2
Reference Transcript
RefSeq:NM_139738.2 PolE2
Other Identifiers
154339_at
1630620_at
38661
GO:0000228
GO:0000278
GO:0003677
GO:0005634
GO:0005694
GO:0006260
GO:0006261
GO:0006281
GO:0008622
GO:0031981
GO:0032877
GO:0042023
GO:0042276
GO:0043226
GO:0045004
GO:0090068
GO:1902969
Participates
as a component of
DNA polymerase epsilon [nucleoplasm] (Drosophila melanogaster)
Inferred From
POLE2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_647995.1
Flybase
FBgn0035644
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O46043
1
Parg [nucleoplasm]
(R-DME-5651826)
0.488
2
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