Reactome | DBF4 [nucleoplasm]

DBF4 [nucleoplasm]

Stable Identifier

R-DME-68387

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Q9NK54

Locations in the PathwayBrowser

Expand all

Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G2/M Checkpoints (Drosophila melanogaster)
    - Activation of ATR in response to replication stress (Drosophila melanogaster)
      - Activation of claspin (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
      - Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Activation of the pre-replicative complex (Drosophila melanogaster)
        
        Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        DDK [nucleoplasm] (Drosophila melanogaster)
        
        DBF4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9NK54

Reference Genes

BioGPS Gene:34974

ENSEMBL:FBgn0000307

Flybase:FBgn0000307

KEGG Gene (Drosophila melanogaster):Dmel_CG5813

Monarch:34974

NCBI Gene:34974

UCSC:Q9NK54

Reference Transcript

Other Identifiers

142469_at

142470_s_at

1640999_at

34974

GO:0003676

GO:0003677

GO:0005634

GO:0005694

GO:0006260

GO:0006325

GO:0006338

GO:0007304

GO:0007307

GO:0008270

GO:0010571

GO:0022414

GO:0030154

GO:0030295

GO:0031431

GO:0036211

GO:0043226

GO:0043539

GO:0043966

GO:0045740

GO:0046716

GO:0046872

GO:0048856

GO:0070775

GO:0072499

GO:0098772

GO:1901987

Participates

as a component of

DDK [nucleoplasm] (Drosophila melanogaster)

Inferred From

DBF4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_523583.2, NP_723965.1, NP_001260499.1

Flybase

FBgn0000307

PRO

Q9NK54

Cite Us!