Reactome | Lerp [plasma membrane]

Lerp [plasma membrane]

Stable Identifier

R-DME-6806532

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

IGF2R, A0A0B4KH68

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        Lerp [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A0A0B4KH68

Gene Names

Lerp

Reference Genes

BioGPS Gene:43223 Lerp

CTD Gene:43223 Lerp

ENSEMBL:FBgn0051072

Flybase:FBgn0051072

KEGG Gene (Drosophila melanogaster):Dmel_CG31072 Lerp

Monarch:43223 Lerp

NCBI Gene:43223 Lerp

Reference Transcript

RefSeq:NM_001276067.1 Lerp

Other Identifiers

150685_at

150686_at

150687_at

150688_at

1632908_s_at

43223

GO:0005515

GO:0005520

GO:0005537

GO:0005737

GO:0005768

GO:0005770

GO:0005794

GO:0005802

GO:0005886

GO:0006892

GO:0006914

GO:0007041

GO:0010508

GO:0016020

GO:0016192

GO:0030136

GO:0031410

GO:0038023

GO:0043226

GO:0048471

GO:0060089

Participates

as a member of

Other forms of this molecule

Lerp [clathrin-coated endocytic vesicle membrane]

Lerp [Golgi membrane]

Lerp [cytoplasmic vesicle membrane]

Lerp [transport vesicle]

Lerp [trans-Golgi network membrane]

Lerp [secretory granule membrane]

Inferred From

IGF2R [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001262996.1

Flybase

FBgn0051072

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