Reactome | phospho-His2A:CG33862 [nucleoplasm]

phospho-His2A:CG33862 [nucleoplasm]

Stable Identifier

R-DME-5682847

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

K63PolyUb-K14,K16,p-S140-H2AFX, P84051

Locations in the PathwayBrowser

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DNA Repair (Drosophila melanogaster)

- DNA Double-Strand Break Repair (Drosophila melanogaster)
  - DNA Double Strand Break Response (Drosophila melanogaster)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
      - RNF8 and RNF168 ubiquitinate H2AFX (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Drosophila melanogaster)
        
        phospho-His2A:CG33862 [nucleoplasm] (Drosophila melanogaster)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Drosophila melanogaster)
        
        phospho-His2A:CG33862 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Drosophila melanogaster)
        
        phospho-His2A:CG33862 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P84051

Gene Names

His2A:CG33862

Reference Genes

BioGPS Gene:318855 His2A:CG33862

BioGPS Gene:3771774 His2A:CG33862

BioGPS Gene:3771783 His2A:CG33862

BioGPS Gene:3771785 His2A:CG33862

BioGPS Gene:3772148 His2A:CG33862

BioGPS Gene:3772278 His2A:CG33862

BioGPS Gene:3772282 His2A:CG33862

BioGPS Gene:3772345 His2A:CG33862

BioGPS Gene:3772351 His2A:CG33862

BioGPS Gene:3772360 His2A:CG33862

BioGPS Gene:3772447 His2A:CG33862

BioGPS Gene:3772448 His2A:CG33862

BioGPS Gene:3772505 His2A:CG33862

BioGPS Gene:3772541 His2A:CG33862

BioGPS Gene:3772565 His2A:CG33862

BioGPS Gene:3772618 His2A:CG33862

BioGPS Gene:3772632 His2A:CG33862

ENSEMBL:FBgn0001196

Flybase:FBgn0001196

KEGG Gene (Drosophila melanogaster):Dmel_CG31618 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33808 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33814 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33817 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33820 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33823 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33826 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33829 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33832 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33835 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33838 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33841 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33844 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33847 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33850 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33862 His2A:CG33862

KEGG Gene (Drosophila melanogaster):Dmel_CG33865 His2A:CG33862

Monarch:318855 His2A:CG33862

Monarch:3771774 His2A:CG33862

Monarch:3771783 His2A:CG33862

Monarch:3771785 His2A:CG33862

Monarch:3772148 His2A:CG33862

Monarch:3772278 His2A:CG33862

Monarch:3772282 His2A:CG33862

Monarch:3772345 His2A:CG33862

Monarch:3772351 His2A:CG33862

Monarch:3772360 His2A:CG33862

Monarch:3772447 His2A:CG33862

Monarch:3772448 His2A:CG33862

Monarch:3772505 His2A:CG33862

Monarch:3772541 His2A:CG33862

Monarch:3772565 His2A:CG33862

Monarch:3772618 His2A:CG33862

Monarch:3772632 His2A:CG33862

NCBI Gene:318855 His2A:CG33862

NCBI Gene:3771774 His2A:CG33862

NCBI Gene:3771783 His2A:CG33862

NCBI Gene:3771785 His2A:CG33862

NCBI Gene:3772148 His2A:CG33862

NCBI Gene:3772278 His2A:CG33862

NCBI Gene:3772282 His2A:CG33862

NCBI Gene:3772345 His2A:CG33862

NCBI Gene:3772351 His2A:CG33862

NCBI Gene:3772360 His2A:CG33862

NCBI Gene:3772447 His2A:CG33862

NCBI Gene:3772448 His2A:CG33862

NCBI Gene:3772505 His2A:CG33862

NCBI Gene:3772541 His2A:CG33862

NCBI Gene:3772565 His2A:CG33862

NCBI Gene:3772618 His2A:CG33862

NCBI Gene:3772632 His2A:CG33862

UCSC:P84051 His2A:CG33862

Reference Transcript

Other Identifiers

1625925_at

318855

3771774

3771783

3771785

3772148

3772278

3772282

3772345

3772351

3772360

3772447

3772448

3772505

3772541

3772565

3772618

3772632

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005634

GO:0005694

GO:0005700

GO:0005704

GO:0006325

GO:0006334

GO:0007526

GO:0030527

GO:0043226

GO:0046982

GO:0048856

GO:0065003

Participates

as a member of

Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

His2A:CG33862 [nucleoplasm]

phospho-His2A:CG33862 [nucleoplasm]

His2A:CG33862 [nucleoplasm]

Inferred From

K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 140 (in Homo sapiens)

Coordinate

140

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 14 (in Homo sapiens)

Coordinate

Modification

K63polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 16 (in Homo sapiens)

Coordinate

Modification

K63polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001027341.1, NP_001027351.1, NP_001027301.1, NP_001027386.1, NP_001027311.1, NP_001027336.1, NP_724343.1, NP_001027361.1, NP_001027321.1, NP_001027292.1, NP_001027306.1, NP_001027381.1, NP_001027331.1, NP_001027346.1, NP_001027356.1, NP_001027316.1, NP_001027326.1

Flybase

FBgn0053865

PRO

P84051

PDB

7PJ1, 4X23, 4QLC, 6PWF, 5WCU, 2NQB, 6DZT, 6PWE, 2PYO

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