Reactome | brv2 [Golgi membrane]

brv2 [Golgi membrane]

Stable Identifier

R-DME-5623393

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

Golgi membrane

Synonyms

PKD2, Q8T8Z2

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Drosophila melanogaster)

- Cilium Assembly (Drosophila melanogaster)
  - Cargo trafficking to the periciliary membrane (Drosophila melanogaster)
    - VxPx cargo-targeting to cilium (Drosophila melanogaster)
      - ARF4:GTP binds VxPx-motifs of membrane proteins (Drosophila melanogaster)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
      - ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Drosophila melanogaster)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
      - ASAP1 stimulates GTPase activity of ARF4 (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
      - Cargo-carrying vesicles bud from the TGN (Drosophila melanogaster)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Drosophila melanogaster)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Drosophila melanogaster)
        
        Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)
        
        brv2 [Golgi membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q8T8Z2

Gene Names

brv2

Reference Genes

BioGPS Gene:39932 brv2

ENSEMBL:FBgn0036712

Flybase:FBgn0036712

Monarch:39932 brv2

NCBI Gene:39932 brv2

UCSC:Q8T8Z2 brv2

Reference Transcript

RefSeq:NM_140713.2 brv2

Other Identifiers

142265_at

1637719_at

39932

GO:0005215

GO:0005262

GO:0005509

GO:0006816

GO:0016020

GO:0050877

GO:0050960

GO:0050982

GO:0055085

GO:0070417

GO:0070588

Participates

as a member of

Homologues of PKD2 [Golgi membrane] (Drosophila melanogaster)

Other forms of this molecule

brv2 [ciliary membrane]

brv2 [Golgi-associated vesicle membrane]

Inferred From

PKD2 [Golgi membrane] (Homo sapiens)

Cross References

RefSeq

NP_648970.2

Flybase

FBgn0036712

Cite Us!