Reactome | Fen1 [nucleoplasm]

Fen1 [nucleoplasm]

Stable Identifier

R-DME-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

FEN1, Q7K7A9

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle, Mitotic (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Synthesis of DNA (Drosophila melanogaster)
      - DNA strand elongation (Drosophila melanogaster)
        
        Lagging Strand Synthesis (Drosophila melanogaster)
        
        Processive synthesis on the lagging strand (Drosophila melanogaster)
        
        Removal of the Flap Intermediate (Drosophila melanogaster)
        
        Removal of remaining Flap (Drosophila melanogaster)
        
        Fen1 [nucleoplasm] (Drosophila melanogaster)

DNA Replication (Drosophila melanogaster)

- Synthesis of DNA (Drosophila melanogaster)
  - DNA strand elongation (Drosophila melanogaster)
    - Lagging Strand Synthesis (Drosophila melanogaster)
      - Processive synthesis on the lagging strand (Drosophila melanogaster)
        
        Removal of the Flap Intermediate (Drosophila melanogaster)
        
        Removal of remaining Flap (Drosophila melanogaster)
        
        Fen1 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7K7A9

Gene Names

Fen1

Reference Genes

BioGPS Gene:36887 Fen1

ENSEMBL:FBgn0025832

Flybase:FBgn0025832

KEGG Gene (Drosophila melanogaster):Dmel_CG8648 Fen1

Monarch:36887 Fen1

NCBI Gene:36887 Fen1

UCSC:Q7K7A9 Fen1

Reference Transcript

RefSeq:NM_079041.2 Fen1

Other Identifiers

144102_at

1624557_at

36887

GO:0000287

GO:0003674

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0004523

GO:0004527

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0006259

GO:0006260

GO:0006281

GO:0006284

GO:0006950

GO:0006974

GO:0008150

GO:0008409

GO:0009056

GO:0009058

GO:0016787

GO:0016788

GO:0017108

GO:0030145

GO:0034641

GO:0034655

GO:0043137

GO:0043167

GO:0043226

GO:0046872

GO:0048256

GO:0090305

GO:0090502

Participant Of

hasComponent

output

FEN1 cleaves displaced ssDNA flaps during MMEJ

input

PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site

Inferred From

FEN1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_523765.1

Flybase

FBgn0025832

PRO

Q7K7A9