Reactome | ADCY8 [plasma membrane]

ADCY8 [plasma membrane]

Stable Identifier

R-DME-53245

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

Q9VP76

Locations in the PathwayBrowser

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Neuronal System (Drosophila melanogaster)

- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - GABA receptor activation (Drosophila melanogaster)
      - GABA B receptor activation (Drosophila melanogaster)
        
        Activation of GABAB receptors (Drosophila melanogaster)
        
        Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - DAG and IP3 signaling (Drosophila melanogaster)
    - CaM pathway (Drosophila melanogaster)
      - Calmodulin induced events (Drosophila melanogaster)
        
        PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        PKA activation (Drosophila melanogaster)
        
        Adenylate cyclase produces cAMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Opioid Signalling (Drosophila melanogaster)
        
        G-protein mediated events (Drosophila melanogaster)
        
        Adenylate cyclase activating pathway (Drosophila melanogaster)
        
        Adenylate cyclase converts ATP into cyclic AMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase inhibitory pathway (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Dissociation of the Gi alpha:G olf complex (Drosophila melanogaster)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Drosophila melanogaster)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
        
        PLC beta mediated events (Drosophila melanogaster)
        
        Ca-dependent events (Drosophila melanogaster)
        
        CaM pathway (Drosophila melanogaster)
        
        Calmodulin induced events (Drosophila melanogaster)
        
        PKA-mediated phosphorylation of CREB (Drosophila melanogaster)
        
        PKA activation (Drosophila melanogaster)
        
        Adenylate cyclase produces cAMP (Drosophila melanogaster)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Drosophila melanogaster)
        
        Adenylate cyclase [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)
- Signaling by Hedgehog (Drosophila melanogaster)
  - Hedgehog 'off' state (Drosophila melanogaster)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Drosophila melanogaster)
      - adenylate cyclases:Mg2+ [plasma membrane] (Drosophila melanogaster)
        
        adenylate cyclases [plasma membrane] (Drosophila melanogaster)
        
        ADCY8 [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VP76

Reference Genes

BioGPS Gene:40333

ENSEMBL:FBgn0024150

Flybase:FBgn0024150

KEGG Gene (Drosophila melanogaster):Dmel_CG10564

Monarch:40333

NCBI Gene:40333

UCSC:Q9VP76

Reference Transcript

Other Identifiers

144007_at

151124_s_at

1628412_at

40333

GO:0000166

GO:0001582

GO:0003824

GO:0004016

GO:0005524

GO:0005886

GO:0006171

GO:0007189

GO:0007623

GO:0009190

GO:0009744

GO:0009975

GO:0010353

GO:0016020

GO:0016829

GO:0016849

GO:0023052

GO:0031000

GO:0035556

GO:0046872

GO:0050877

GO:0050896

GO:0055086

GO:1901135

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Drosophila melanogaster)

as a member of

Adenylate cyclase [plasma membrane] (Drosophila melanogaster)

Inferred From

ADCY8 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_524194.3, NP_001246857.1

Flybase

FBgn0024150

IntEnz

4.6.1.1

PRO

Q9VP76

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