Reactome | APEX1 [nucleoplasm]

APEX1 [nucleoplasm]

Stable Identifier

R-DME-50119

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

P27864

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27864

Reference Genes

BioGPS Gene:33500

ENSEMBL:FBgn0004584

Flybase:FBgn0004584

KEGG Gene (Drosophila melanogaster):Dmel_CG3178

Monarch:33500

NCBI Gene:33500

Reference Transcript

RefSeq:NM_057493.4

Other Identifiers

143488_at

1625109_at

33500

GO:0003677

GO:0003824

GO:0003906

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0006281

GO:0006284

GO:0006974

GO:0008081

GO:0008311

GO:0008408

GO:0016787

GO:0043226

GO:0046872

GO:0052720

GO:0070182

GO:0140097

Participates

as a component of

LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:AP-dsDNA [nucleoplasm] (Drosophila melanogaster)

as an input of

Displacement of TDG glycosylase by APEX1 at the AP site (Drosophila melanogaster)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)

Inferred From

APEX1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_476841.1

Flybase

FBgn0004584

IntEnz

3.1.11.2

PRO

P27864

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