JET binds cytosolic TIM, facilitating its ubiquitination

Stable Identifier
R-DME-432401
Type
Reaction [uncertain]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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JET binds cytosolic TIM, facilitating its ubiquitination
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There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. This interaction targets TIM for ubiquitination, marking it for processing by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
16794082 JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

Sehgal, A, Zheng, X, Koh, K

Science 2006
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Szabo, G, Stanewsky, R, Chen, KF

Curr Biol 2009
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Catalyst Activity

ubiquitin ligase-substrate adaptor activity of JET [cytosol]

Physical Entity
JET [cytosol] (Drosophila melanogaster)
Activity
ubiquitin ligase-substrate adaptor activity (GO:1990756)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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