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TIM [cytosol]
Stable Identifier
R-DME-432355
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Degradation of TIM (Drosophila melanogaster)
CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
TIM:CRY [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)
UBI-P63E:TIM:JET [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)
TIM:CRY [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
UBI-P63E:TIM:JET [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
Dephosphorylation of PER (Drosophila melanogaster)
Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO (Drosophila melanogaster)
TIM:PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
TIM:Phospho (multi-site 1) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
Dephosphorylation of TIM (Drosophila melanogaster)
PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO (Drosophila melanogaster)
TIM:Phospho (multi-site 2) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
Phosphorylation of PER and TIM (Drosophila melanogaster)
Phosphorylated PER binds to TIM (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
TIM:Phospho (multi-site 1) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)
TIM:Phospho (multi-site 1) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
TIM:Phospho (multi-site 2) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
TIM is phosphorylated by CK2 (Drosophila melanogaster)
TIM:Phospho (multi-site 2) PER:DCO [cytosol] (Drosophila melanogaster)
TIM [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P49021 tim
Gene Names
tim, CG3234
Chain
chain:1-1398
Reference Genes
BioGPS Gene:33571 tim
KEGG Gene (Drosophila melanogaster):Dmel_CG3234 tim
Monarch:33571 tim
NCBI Gene:33571 tim
UCSC:P49021 tim
Reference Transcript
RefSeq:NM_001014463.4 tim
RefSeq:NM_164542.5 tim
RefSeq:NM_164541.6 tim
RefSeq:NM_001144309.4 tim
RefSeq:NM_164540.4 tim
RefSeq:NM_001201757.2 tim
RefSeq:NM_001144308.3 tim
RefSeq:NM_001038783.3 tim
Other Identifiers
142154_at
151485_s_at
1631468_a_at
1634188_a_at
33571
GO:0000076
GO:0000122
GO:0000228
GO:0003013
GO:0003053
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0007617
GO:0007620
GO:0007622
GO:0008062
GO:0008134
GO:0009648
GO:0009649
GO:0016192
GO:0022414
GO:0023052
GO:0031298
GO:0042306
GO:0042749
GO:0043111
GO:0043226
GO:0045187
GO:0045475
GO:0046957
GO:0046982
GO:0048471
GO:0048478
GO:0048511
GO:0048512
GO:0048856
GO:0050764
GO:0050766
GO:0060086
GO:0071482
GO:2000678
Participates
as an output of
PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)
as a component of
TIM:PER:DCO [cytosol] (Drosophila melanogaster)
UBI-P63E:TIM:JET [cytosol] (Drosophila melanogaster)
TIM:CRY [cytosol] (Drosophila melanogaster)
TIM:Phospho (multi-site 1) PER:DCO [cytosol] (Drosophila melanogaster)
TIM:Phospho (multi-site 2) PER:DCO [cytosol] (Drosophila melanogaster)
as an input of
CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)
Phosphorylated PER binds to TIM (Drosophila melanogaster)
Other forms of this molecule
Phospho TIM [cytosol]
Phospho TIM [nucleoplasm]
Cross References
RefSeq
NP_722914.3
,
NP_722912.3
,
NP_001137780.2
,
NP_722913.3
,
NP_001137781.2
,
NP_001014463.2
,
NP_001033872.2
,
NP_001188686.2
Flybase
FBgn0014396
PRO
P49021
PDB
8DD7
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07663-1 PER
0.592
2
UniProt:P07663 per
5
PER [nucleoplasm]
(R-DME-432352)
PER [cytosol]
(R-DME-432515)
Phospho (multi-site 1) PER [cytosol]
(R-DME-881928)
Phospho (multi-site 2) PER [cytosol]
(R-DME-881960)
Phospho (multi-site 2) PER [nucleoplasm]
(R-DME-881979)
0.502
2
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