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DCC interaction with Robo-1
Stable Identifier
R-DME-428953
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
plasma membrane
ReviewStatus
5/5
General
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Dcc and Robo-1 heterodimerize via conserved sequence elements in their cytoplasmic domains, namely CC1 (conserved cytoplasmic region1) in Robo-1 and P3 in Dcc. The formation of this complex is dependent on the previous interaction between Robo and its ligand (Slit). This physical interaction between Robo:Slit and Dcc silences the attractive effect of Netrin:Dcc and regulates the midline crossing of axons.
From the analysis of multiple double mutant combinations of the Robo:Slit and Netrin:Dcc receptor-ligand pairs, it was deduced that Robo repulsion on its own is sufficient to prevent commissural axons from re-crossing the midline, and that Netrin:Dcc is not the only source of attraction at the midline (Garbe and Bashaw 2007).
Literature References
PubMed ID
Title
Journal
Year
17392474
Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila
Bashaw, GJ
,
Garbe, DS
J Neurosci
2007
Participants
Input
Frazzled [plasma membrane]
(Drosophila melanogaster)
Robo:Slit_DROME [plasma membrane]
(Drosophila melanogaster)
Output
DCC:Robo:Slit [plasma membrane]
(Drosophila melanogaster)
Orthologous Events
DCC interaction with ROBO1 (Homo sapiens)
Authored
Garapati, P V (2008-09-05)
Reviewed
Jaworski, A (2017-07-31)
Cooper, HM (2010-02-16)
Created
Garapati, P V (2009-07-13)
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