Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Pi3K92E [plasma membrane]
Stable Identifier
R-DME-392274
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
PIK3CD, P91634
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K delta [cytosol] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K delta [cytosol] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
BCAP Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)
CD19 Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL ubiquitinates PI3K (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
K63polyUb-PI3K delta [cytosol] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K delta [cytosol] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
BCAP Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
CD19 Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
BCAP Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
CD19 Signalosome [plasma membrane] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Pi3K92E [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P91634 Pi3K92E
Gene Names
Pi3K92E, CG4141, Dmel_CG4141
Reference Genes
BioGPS Gene:42446 Pi3K92E
CTD Gene:42446 Pi3K92E
KEGG:dme:Dmel_CG4141 Pi3K92E
Monarch:42446 Pi3K92E
NCBI Gene:42446 Pi3K92E
UCSC:P91634 Pi3K92E
Reference Transcript
RefSeq:NM_142645.3 Pi3K92E
RefSeq:NM_001275841.1 Pi3K92E
RefSeq:NM_169910.2 Pi3K92E
Other Identifiers
143789_at
1631594_s_at
42446
GO:0000166
GO:0002164
GO:0002168
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0006629
GO:0006914
GO:0006979
GO:0007346
GO:0007552
GO:0008286
GO:0008361
GO:0009267
GO:0010884
GO:0016301
GO:0016303
GO:0016477
GO:0016740
GO:0022414
GO:0030307
GO:0030536
GO:0030707
GO:0032060
GO:0033500
GO:0034330
GO:0035005
GO:0035099
GO:0035205
GO:0035212
GO:0035264
GO:0036092
GO:0036099
GO:0036335
GO:0040014
GO:0042127
GO:0042593
GO:0042691
GO:0043491
GO:0045572
GO:0045615
GO:0045727
GO:0045793
GO:0045887
GO:0046622
GO:0046854
GO:0046934
GO:0048010
GO:0048015
GO:0048167
GO:0048169
GO:0048477
GO:0048542
GO:0048813
GO:0048856
GO:0048870
GO:0050773
GO:0050920
GO:0051823
GO:0055088
GO:0055115
GO:0060074
GO:1903688
GO:1904263
GO:1904801
GO:2000252
Participates
as a component of
K63polyUb-PI3K delta [cytosol] (Drosophila melanogaster)
PI3K delta [cytosol] (Drosophila melanogaster)
PIK3CD:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
PI3K92E [cytosol]
Pi3K92E [cytosol]
Pi3K92E [cytosol]
Inferred From
PIK3CD [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001262770.1
,
NP_732536.1
,
NP_650902.1
ENSEMBL
FBpp0306705
,
FBgn0015279
,
FBpp0083348
,
FBpp0083349
,
FBtr0334643
,
FBtr0083941
,
FBtr0083940
FlyBase
FBgn0015279
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text