Reactome | Fbw5 [cytosol]

Fbw5 [cytosol]

Stable Identifier

R-DME-391286

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

FBXW5, Q9VMI1

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
    - Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
      - Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - Polyubiquitination of substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
        
        E3:Ub:substrate [cytosol] (Drosophila melanogaster)
        
        E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Neddylation (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
        
        CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        F-box protein [cytosol] (Drosophila melanogaster)
        
        Fbw5 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VMI1

Gene Names

Fbw5

Reference Genes

BioGPS Gene:33854 Fbw5

ENSEMBL:FBgn0031773

Flybase:FBgn0031773

KEGG Gene (Drosophila melanogaster):Dmel_CG9144 Fbw5

Monarch:33854 Fbw5

NCBI Gene:33854 Fbw5

UCSC:Q9VMI1 Fbw5

Reference Transcript

RefSeq:NM_135145.2 Fbw5

Other Identifiers

145868_at

1635843_at

33854

GO:0005515

GO:0006511

GO:0016567

GO:0019005

GO:0030163

GO:0031146

GO:0036211

GO:0043161

GO:0045732

GO:0080008

Participates

as a member of

F-box protein [cytosol] (Drosophila melanogaster)

Inferred From

FBXW5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_608989.1

Flybase

FBgn0031773

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