Reactome | Phosphorylated HPO dimer phosphorylates WTS

Phosphorylated HPO dimer phosphorylates WTS

Stable Identifier

R-DME-390112

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylated HPO dimer phosphorylates WTS

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Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates Warts (WTS) kinase at unknown residues.

Literature References

PubMed ID	Title	Journal	Year
14502295	The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila Tapon, N, Léopold, P, Pantalacci, S	Nat Cell Biol	2003
12941273	hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts Wu, S, Pan, D, Dong, J, Huang, J	Cell	2003

Participants

Input

Output

Participates

as an event of

Formation of the Hippo kinase cassette (Drosophila melanogaster)

Catalyst Activity

protein serine/threonine kinase activity of MATS:Phospho HPO dimer:Phospho SAV:WTS [cytosol]

Physical Entity

MATS:Phospho HPO dimer:Phospho SAV:WTS [cytosol] (Drosophila melanogaster)

Activity

protein serine/threonine kinase activity (GO:0004674)

Authored

Williams, MG (2009-01-23)

Reviewed

Irvine, KD (2009-11-25)

Created

Williams, MG (2009-01-23)

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