Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EcR [nucleoplasm]
Stable Identifier
R-DME-375500
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
NR1H2, P34021
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Nuclear Receptor transcription pathway (Drosophila melanogaster)
Formation of NR-MED1 Coactivator Complex (Drosophila melanogaster)
NR [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NR-MED1 Coactivator Complex [nucleoplasm] (Drosophila melanogaster)
NR [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Formation of NR-NCOR Corepressor Complex (Drosophila melanogaster)
NR [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NR-NCOR CoRepressor Complex [nucleoplasm] (Drosophila melanogaster)
NR [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
SUMOylation (Drosophila melanogaster)
SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
SUMOylation of intracellular receptors (Drosophila melanogaster)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)
NR1H2:hydroxycholesterol [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
NR1H2 and NR1H3-mediated signaling (Drosophila melanogaster)
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Drosophila melanogaster)
Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Drosophila melanogaster)
Co-repressor complex dissociates from the transcription unit of the ABCA1 gene (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
Transport of small molecules (Drosophila melanogaster)
Plasma lipoprotein assembly, remodeling, and clearance (Drosophila melanogaster)
Plasma lipoprotein clearance (Drosophila melanogaster)
VLDLR internalisation and degradation (Drosophila melanogaster)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)
EcR [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P34021
Gene Names
EcR
Reference Genes
BioGPS Gene:35540 EcR
CTD Gene:35540 EcR
ENSEMBL:FBgn0000546
FlyBase:FBgn0000546
KEGG:dme:Dmel_CG1765 EcR
Monarch:35540 EcR
NCBI Gene:35540 EcR
UCSC:P34021 EcR
Reference Transcript
RefSeq:NM_165463.2 EcR
RefSeq:NM_165462.2 EcR
RefSeq:NM_165465.3 EcR
RefSeq:NM_001169590.2 EcR
RefSeq:NM_165461.3 EcR
RefSeq:NM_165464.3 EcR
Other Identifiers
146672_at
154377_at
1632796_s_at
35540
GO:0000122
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001046
GO:0001222
GO:0001223
GO:0001228
GO:0001752
GO:0002164
GO:0003677
GO:0003700
GO:0004879
GO:0005102
GO:0005496
GO:0005515
GO:0005634
GO:0005694
GO:0005700
GO:0005737
GO:0006355
GO:0006357
GO:0006911
GO:0006914
GO:0007155
GO:0007281
GO:0007291
GO:0007298
GO:0007390
GO:0007422
GO:0007443
GO:0007476
GO:0007488
GO:0007552
GO:0007616
GO:0008230
GO:0008231
GO:0008232
GO:0008258
GO:0008270
GO:0008289
GO:0008340
GO:0008362
GO:0008544
GO:0010002
GO:0010506
GO:0010629
GO:0012501
GO:0016241
GO:0016319
GO:0016322
GO:0018990
GO:0022414
GO:0030154
GO:0030425
GO:0035053
GO:0035071
GO:0035072
GO:0035073
GO:0035075
GO:0035076
GO:0035100
GO:0035180
GO:0035188
GO:0035193
GO:0035206
GO:0035297
GO:0040003
GO:0040034
GO:0042220
GO:0042632
GO:0042803
GO:0043065
GO:0043226
GO:0043457
GO:0043565
GO:0045892
GO:0045893
GO:0045938
GO:0045944
GO:0046872
GO:0046982
GO:0048102
GO:0048477
GO:0048738
GO:0048813
GO:0048856
GO:0048870
GO:0050877
GO:0060089
GO:0061024
GO:0090575
GO:0140110
GO:0140297
GO:1904799
GO:1904801
Participates
as a component of
NR1H2:hydroxycholesterol [nucleoplasm] (Drosophila melanogaster)
NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
as a member of
NR [nucleoplasm] (Drosophila melanogaster)
This entity regulates
Positively
MYLIP dimer ubiquitinates VLDLR on Lys-839
(Drosophila melanogaster)
Other forms of this molecule
EcR [cytosol]
EcR [nucleoplasm]
EcR [nucleoplasm]
EcR [nucleoplasm]
EcR [nucleoplasm]
Inferred From
NR1H2,NR1H3 [nucleoplasm]
(Homo sapiens)
NR1H2 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
FBpp0085352
,
FBtr0302439
,
FBpp0291631
,
FBtr0086011
ZINC - Substances
ECR_DROME
ZINC - Biogenic
ECR_DROME
ZINC target
P34021
PRO
P34021
ZINC - Predictions - Purchasable
ECR_DROME
PDB
1R0O
,
1R0N
,
2HAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24294 Q24294
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text