AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene

Stable Identifier
R-DME-354289
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene
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The 'repressosome complex' recruits the histone deacetylase RPD3 aka HDAC1 to the Relish target gene resulting in repression of its transcription. This is an example of the JNK pathway downregulating the Imd pathway.
Literature References
PubMed ID Title Journal Year
15640802 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules

Kim, YJ, Kim, J, Kim, T, Yoon, J, Yoon, JH, Song, YH, Kim-Ha, J, Lee, WB, Cho, H, Kim, SN

Nat Immunol 2005
17803358 Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila

Kim, YJ, Shim, J, Cho, HS, Kim, J, Kim, LK, Choi, UY, Kim-Ha, J, Lee, WB, Lee, JS, Jeong, K

PLoS Biol 2007
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Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-06-17)
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