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DGO binds to PK
Stable Identifier
R-DME-350403
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Planar Cell Polarity pathway (Drosophila melanogaster)
Negative feedback loop regulates asymmetric localisation (Drosophila melanogaster)
DGO binds to PK (Drosophila melanogaster)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the cytosol, Diego (DGO) can bind to Prickle (PK). This may result in there being less DGO to bind to and stabilise the Frizzled (FZ):Dishevelled (DSH) complex.
Literature References
PubMed ID
Title
Journal
Year
15306567
Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes
Klein, TJ
,
Eaton, S
,
Jenny, A
,
Das, G
,
Mlodzik, M
Development
2004
Participants
Input
DGO [cytosol]
(Drosophila melanogaster)
PK [cytosol]
(Drosophila melanogaster)
Output
PK:DGO [cytosol]
(Drosophila melanogaster)
Participates
as an event of
Negative feedback loop regulates asymmetric localisation (Drosophila melanogaster)
Authored
Williams, MG (2008-05-20)
Reviewed
Axelrod, JD (2009-11-19)
Created
Williams, MG (2008-05-19)
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