PK binds to DSH

Stable Identifier
R-DME-350400
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
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The PET/LIM domain of Prickle (PK) interacts with DEP domain and C-terminus of Dishevelled (DSH). The DEP domain is required by DSH for membrane localisation. Binding of Diego (DGO) and PK to DSH is mutually exclusive. PK binding to DSH prevents FZ PCP signalling.

Literature References
PubMed ID Title Journal Year
12015986 Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling

Tree, DR, Shulman, JM, Rousset, R, Scott, MP, Gubb, D, Axelrod, JD

Cell 2002
15937478 Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding

Jenny, A, Reynolds-Kenneally, J, Das, G, Burnett, M, Mlodzik, M

Nat Cell Biol 2005
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