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Tip60 [nucleoplasm]
Stable Identifier
R-DME-3321979
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
KAT5, Q960X4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
DNA Damage/Telomere Stress Induced Senescence (Drosophila melanogaster)
KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN activates ATM (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
DNA Double Strand Break Response (Drosophila melanogaster)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
ATM phosphorylates EYA1-4 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
ATM phosphorylates MDC1 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
ATM phosphorylates NBN (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MDC1 associates with gamma-H2AFX at nuclear foci (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Sensing of DNA Double Strand Breaks (Drosophila melanogaster)
KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN activates ATM (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
ATM phosphorylates RBBP8 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
CDK2 phosphorylates RBBP8 (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Estrogen-dependent gene expression (Drosophila melanogaster)
Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Drosophila melanogaster)
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Formation of the beta-catenin:TCF transactivating complex (Drosophila melanogaster)
Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
Tip60 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q960X4
Gene Names
Tip60
Reference Genes
BioGPS Gene:31362 Tip60
CTD Gene:31362 Tip60
ENSEMBL:FBgn0026080
FlyBase:FBgn0026080
KEGG:dme:Dmel_CG6121 Tip60
Monarch:31362 Tip60
NCBI Gene:31362 Tip60
UCSC:Q960X4 Tip60
Reference Transcript
RefSeq:NM_131923.4 Tip60
RefSeq:NM_001272305.1 Tip60
Other Identifiers
154558_at
1635824_at
31362
GO:0000123
GO:0000724
GO:0000785
GO:0003682
GO:0003712
GO:0003824
GO:0004402
GO:0005634
GO:0005694
GO:0005705
GO:0006281
GO:0006310
GO:0006325
GO:0006338
GO:0006355
GO:0006357
GO:0006974
GO:0007399
GO:0008270
GO:0010468
GO:0016740
GO:0016746
GO:0032991
GO:0035267
GO:0043524
GO:0046872
GO:0046972
GO:0048167
GO:0048856
GO:0061733
GO:0140096
GO:0140861
GO:1990188
GO:2000331
Participates
as a member of
histone acetyltransferases [nucleoplasm] (Drosophila melanogaster)
as an input of
Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)
as a component of
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Drosophila melanogaster)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
ATM dimer:KAT5 [nucleoplasm] (Drosophila melanogaster)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Drosophila melanogaster)
Inferred From
KAT5 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_572151.1
,
NP_001259234.1
ENSEMBL
FBtr0333186
,
FBgn0026080
,
FBpp0070636
,
FBtr0070668
,
FBpp0305388
FlyBase
FBgn0026080
PRO
Q960X4
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