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Usp7 [nucleoplasm]
Stable Identifier
R-DME-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
USP7, Q9VYQ8
Locations in the PathwayBrowser
Expand all
DNA Repair (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Expression and Degradation (Drosophila melanogaster)
Regulation of TP53 Degradation (Drosophila melanogaster)
USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN localization (Drosophila melanogaster)
USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)
Usp7 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VYQ8
Gene Names
Usp7
Reference Genes
BioGPS Gene:32169 Usp7
ENSEMBL:FBgn0030366
FlyBase:FBgn0030366
KEGG:dme:Dmel_CG1490 Usp7
Monarch:32169 Usp7
NCBI Gene:32169 Usp7
UCSC:Q9VYQ8 Usp7
Reference Transcript
RefSeq:NM_132551.3 Usp7
Other Identifiers
144913_at
1630505_a_at
1631564_at
32169
GO:0000792
GO:0003824
GO:0004197
GO:0004843
GO:0005515
GO:0005634
GO:0005694
GO:0005700
GO:0005829
GO:0006508
GO:0006511
GO:0008234
GO:0016579
GO:0016787
GO:0031453
GO:0031647
GO:0032991
GO:0035331
GO:0043226
GO:0045880
GO:0140096
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Drosophila melanogaster)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
Usp7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_572779.2
ENSEMBL
FBpp0073474
,
FBtr0073641
PRO
Q9VYQ8
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