Reactome | KDM4B [nucleoplasm]

KDM4B [nucleoplasm]

Stable Identifier

R-DME-3214396

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Q9V333

Locations in the PathwayBrowser

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DNA Repair (Drosophila melanogaster)

- DNA Double-Strand Break Repair (Drosophila melanogaster)
  - DNA Double Strand Break Response (Drosophila melanogaster)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Drosophila melanogaster)
      - ATM phosphorylates HERC2 (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
      - KDM4A,B bind H4K20Me2 (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
      - RNF8 and RNF168 ubiquitinate H2AFX (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)
        
        KDM4B [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V333

Reference Genes

BioGPS Gene:35744

ENSEMBL:FBgn0033233

Flybase:FBgn0033233

KEGG Gene (Drosophila melanogaster):Dmel_CG15835

Monarch:35744

NCBI Gene:35744

UCSC:Q9V333

Reference Transcript

RefSeq:NM_136487.4

Other Identifiers

142811_at

1635774_at

35744

GO:0000785

GO:0000792

GO:0003824

GO:0005634

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0010468

GO:0010628

GO:0016491

GO:0016706

GO:0032452

GO:0032454

GO:0036211

GO:0043226

GO:0045892

GO:0046872

GO:0051213

GO:0051864

GO:0140096

GO:0140681

GO:0140684

GO:0140760

Participates

as a member of

Homologues of KDM4B [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

K48PolyUb-KDM4B [nucleoplasm]

Inferred From

KDM4B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_610331.1

Flybase

FBgn0033233

PRO

Q9V333

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