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MCM8 [nucleoplasm]
Stable Identifier
R-DME-3006646
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
Q9VF30
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Activation of claspin (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)
MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
DNA Replication Pre-Initiation (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)
MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Assembly of the pre-replicative complex (Drosophila melanogaster)
CDC6 association with the ORC:origin complex (Drosophila melanogaster)
CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)
CDC6:MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 binds CDC6 (Drosophila melanogaster)
CDC6:MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
Switching of origins to a post-replicative state (Drosophila melanogaster)
Orc1 removal from chromatin (Drosophila melanogaster)
Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
MCM8 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VF30
Reference Genes
BioGPS Gene:49241
ENSEMBL:FBgn0003227
Flybase:FBgn0003227
KEGG Gene (Drosophila melanogaster):Dmel_CG31293
Monarch:49241
NCBI Gene:49241
Reference Transcript
RefSeq:NM_169674.2
RefSeq:NM_001275686.1
Other Identifiers
149977_at
151050_at
1625964_at
49241
GO:0000166
GO:0003677
GO:0003678
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0006260
GO:0006270
GO:0006310
GO:0007049
GO:0007131
GO:0008094
GO:0016787
GO:0017116
GO:0022414
GO:0032508
GO:0042555
GO:0043226
GO:0046872
GO:0051301
GO:0051321
GO:0140013
GO:0140097
GO:0140657
Participates
as an input of
MCM8 binds CDC6 (Drosophila melanogaster)
as a component of
CDC6:MCM8 [nucleoplasm] (Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm] (Drosophila melanogaster)
Inferred From
MCM8 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001262615.1
,
NP_732072.1
Flybase
FBgn0003227
PRO
Q9VF30
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