Full-length SNK is cleaved by GD serine protease

Stable Identifier
R-DME-214953
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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In dorsoventral patterning, the full-length serine protease zymogen, Snake (SNK), is cleaved by active Gastrulation Defective (GD) serine protease between residues Leu185 and Ile186. The removal of the prodomain results in an active SNK protease.
Literature References
PubMed ID Title Journal Year
12493753 Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites

Rose, T, Di Cera, E, Cantwell, AM, LeMosy, EK, Banerjee-Roy, D, Skeath, JB

J Biol Chem 2003
11350927 Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate

Dissing, M, Giordano, H, DeLotto, R

EMBO J 2001
11296245 Activation of a protease cascade involved in patterning the Drosophila embryo

Hashimoto, C, Tan, YQ, LeMosy, EK

Proc Natl Acad Sci U S A 2001
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of GD [extracellular region]

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