WEK and MYD88:TUB bind to the TL receptor

Stable Identifier
R-DME-214853
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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WEK and MYD88:TUB bind to the TL receptor
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Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation. In dorsoventral patterning in Drosophila embryos, the zinc finger containing adaptor protein Weckle, (WEK) binds to both the TL receptor cytoplasmic domain and the adaptor protein MYD88, which in complex with Tube (TUB), also binds to TL. In addition, WEK forms dimers through its N-terminal region.
Literature References
PubMed ID Title Journal Year
16782008 Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

Imler, JL, Lin, HP, Hyvert, Y, Chen, LY, Hsu, JC, Wang, JC, Perrimon, N

Curr Biol 2006
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Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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