Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'

Stable Identifier
R-DME-214847
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'
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Once phosphorylated, Cactus (CACT), in complex with the Dorsal (DL) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.
Literature References
PubMed ID Title Journal Year
10072384 Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

Huang, LH, Steward, R, Drier, EA

Genes Dev 1999
8948598 A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo

Wasserman, SA, Karin, M, Towb, P, Allen, JL, Galindo, RL, Reach, M

Dev Biol 1996
10660298 Cactus-independent regulation of Dorsal nuclear import by the ventral signal

Steward, R, Govind, S, Drier, EA

Curr Biol 2000
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Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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