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PGRP-LE [cytosol]
Stable Identifier
R-DME-214412
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Imd pathway (Drosophila melanogaster)
Catalytic processing of the nuclear factor, REL (Drosophila melanogaster)
Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' (Drosophila melanogaster)
Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:Phospho REL [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:REL [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Phosphorylated REL is cleaved by and dissociates from DREDD (Drosophila melanogaster)
Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:Phospho REL [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Formation of the PGN:PGRP-LC/LE receptor 'signalling complex' (Drosophila melanogaster)
Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' (Drosophila melanogaster)
Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Peptidoglycan bound PGRP-LC/LE oligomerises (Drosophila melanogaster)
Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE (Drosophila melanogaster)
Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' (Drosophila melanogaster)
REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:REL [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE oligomer [cytosol] (Drosophila melanogaster)
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
PGRP-LE [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VXN9 PGRP-LE
Gene Names
PGRP-LE, CG8995
Chain
chain:1-345
Reference Genes
BioGPS Gene:32534 PGRP-LE
KEGG Gene (Drosophila melanogaster):Dmel_CG8995 PGRP-LE
Monarch:32534 PGRP-LE
NCBI Gene:32534 PGRP-LE
Reference Transcript
RefSeq:NM_001258766.3 PGRP-LE
RefSeq:NM_132850.4 PGRP-LE
Other Identifiers
151798_at
1638119_at
32534
GO:0002376
GO:0003824
GO:0005515
GO:0005576
GO:0005829
GO:0008270
GO:0008340
GO:0008745
GO:0009253
GO:0016192
GO:0016787
GO:0023052
GO:0042742
GO:0042834
GO:0045087
GO:0045089
GO:0050766
GO:0050829
GO:0050830
GO:0051607
GO:0061057
GO:0098542
GO:1901135
Participates
as an input of
Monomeric PGN binds to PGRP-LE in the cytosol (Drosophila melanogaster)
as a component of
Mono PGN:PGRP-LE [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_573078.1
,
NP_001245695.1
Flybase
FBgn0030695
PRO
Q9VXN9
PDB
2CB3
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VJ31 Q9VJ31
0.488
2
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